Radiotherapy and immune checkpoint blockade for melanoma: A promising combinatorial strategy in need of further investigation Journal Article


Authors: Escorcia, F. E.; Postow, M. A.; Barker, C. A.
Article Title: Radiotherapy and immune checkpoint blockade for melanoma: A promising combinatorial strategy in need of further investigation
Abstract: Radiotherapy and immune checkpoint blockade are effective treatments for melanoma. Recent preclinical studies have suggested an interaction of radiotherapy and immune checkpoint blockade. Retrospective clinical studies, as well as a small number of prospective studies, have been undertaken to explore this interaction in patients with melanoma. In this review, we present the results of clinical studies combining radiotherapy and immune checkpoint blockade and conclude that this is a promising strategy worth of further investigation. © 2017 Wolters Kluwer Health, Inc. All rights reserved.
Keywords: ipilimumab; melanoma; radiotherapy; immunotherapy; radiation therapy; stereotactic radiosurgery; ctla-4; pd-1; pd-l1; immune checkpoint blockade; nivolumab; pembrolizumab
Journal Title: The Cancer Journal
Volume: 23
Issue: 1
ISSN: 1528-9117
Publisher: Lippincott Williams & Wilkins  
Date Published: 2017-01-01
Start Page: 32
End Page: 39
Language: English
DOI: 10.1097/ppo.0000000000000236
PROVIDER: scopus
PMCID: PMC5300083
PUBMED: 28114252
DOI/URL:
Notes: Review -- Export Date: 2 March 2017 -- Source: Scopus
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MSK Authors
  1. Michael Andrew Postow
    185 Postow
  2. Christopher Barker
    113 Barker