Outcome of patients with a history of bilateral retinoblastoma treated for a second malignancy: The Memorial Sloan-Kettering experience Journal Article
| Authors: | Dunkel, I. J.; Gerald, W. L.; Rosenfield, N. S.; Strong, E. W.; Abramson, D. H.; Ghavimi, F. |
| Article Title: | Outcome of patients with a history of bilateral retinoblastoma treated for a second malignancy: The Memorial Sloan-Kettering experience |
| Abstract: | Background. Patients with bilateral retinoblastoma are well recognized to have a high risk of developing a second malignancy, but there are little published data regarding the outcome of these patients following treatment. Patients and Methods. We identified 15 patients with a history of bilateral retinoblastoma who received treatment at Memorial Sloan-Kettering Cancer Center for a newly diagnosed second malignancy. The median age of second tumor occurrence was 18 years (range 10-32 years). Three patients later had a third tumor (18 tumors total). Tumor sites included facial structures in 14 cases and extremities in 4. Histologies included osteosarcoma (5), leiomyosarcoma (5), high-grade spindle cell sarcoma (3), malignant fibrous histiocytoma (3), malignant mesenchymoma (1), and angiosarcoma (1). Results. Nine patients are alive: 7 disease free at a median of 29 months (range 6-214 months) and 2 with residual disease 59 and 148 months post-diagnosis of the second malignancy. Six patients have died at a median of 31 months (range 16-98 months) after diagnosis of the second malignancy. Conclusions. Patients with a history of bilateral retinoblastoma who develop a second malignancy may enjoy extended periods of survival. Aggressive therapy appropriate to the tumor histology and site is indicated. (C) 1998 Wiley-Liss, Inc. |
| Keywords: | chemotherapy, adjuvant; neoplasms; retinoblastoma; survivors; surgery; radiation therapy; children; childhood-cancer; 2nd primary tumors; bone sarcomas; neoplasm, second primary |
| Journal Title: | Medical and Pediatric Oncology |
| Volume: | 30 |
| Issue: | 1 |
| ISSN: | 0098-1532 |
| Publisher: | Wiley Liss |
| Date Published: | 1998-01-01 |
| Start Page: | 59 |
| End Page: | 62 |
| Language: | English |
| ACCESSION: | WOS:A1998YD97900014 |
| DOI: | 10.1002/(sici)1096-911x(199801)30:1<59::aid-mpo14>3.0.co;2-3 |
| PROVIDER: | wos |
| PUBMED: | 9371391 |
| Notes: | Article -- Source: Wos |
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