Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor Journal Article

   

Authors:	Hata, A.; Lagna, G.; Massague, J.; Hemmati-Brivanlou, A.
Article Title:	Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor
Abstract:	Bone morphogenetic protein (BMP) receptors signal by phosphorylating Smad1, which then associates with Smad4; this complex moves into the nucleus and activates transcription. Here we report the existence of a natural inhibitor of this process, Smad6, a longer version of the previously reported JV15-1. In Xenopus embryos and in mammalian cells, Smad6 specifically blocks signaling by the BMP/Smad1 pathway. Smad6 inhibits BMP/Smad1 signaling without interfering with receptor-mediated phosphorylation of Smad1. Smad6 specifically competes with Smad4 for binding to receptor-activated Smad1, yielding an apparently inactive Smad1-Smad6 complex. Therefore, Smad6 selectively antagonizes MBP-activated Smad1 by acting as a Smad4 decoy.
Keywords:	smad proteins; receptor; xenopus; expression; cells; growth-factor-beta; complex; antagonist; mammalian; tgf beta; mesoderm induction; mad-related protein; bone morphogenetic protein-4; neural fate; spemann organizer; xenopus-embryos; bmp receptors; activin-a
Journal Title:	Genes and Development
Volume:	12
Issue:	2
ISSN:	0890-9369
Publisher:	Cold Spring Harbor Laboratory Press
Date Published:	1998-01-15
Start Page:	186
End Page:	197
Language:	English
ACCESSION:	WOS:000072096400005
DOI:	10.1101/gad.12.2.186
PROVIDER:	wos
PMCID:	PMC316444
PUBMED:	9436979
Notes:	Article -- Source: Wos

https://synapse.mskcc.org/synapse/works/has_related_data_chk/105272