Risk assessment for metastatic testis cancer Journal Article
| Authors: | McCaffrey, J. A.; Bajorin, D. F.; Motzer, R. J. |
| Article Title: | Risk assessment for metastatic testis cancer |
| Abstract: | Metastatic germ cell tumors represent a model for curable malignancy, with 70% to 80% of patients cured of their disease. Patients with a good prognosis are likely to be cured, and the aim of investigation is to maintain the high cure rate while minimizing toxicity. For patients who fail to achieve a complete response (CR) to therapy, or who relapse after achieving CR, the prognosis is poor - these patients have become the focus of more intensive treatment to increase the cure rate. Distinguishing which patients will require more aggressive therapy ab initio has been the goal of successive attempts to stratify patients into either good- or poor-risk groups to tailor treatment accordingly. A number of analyses have yielded variable factors and differing schemas to classify patients, culminating in the International Germ Cell Consensus Group whose findings have been utilized to develop the new testicular cancer staging system for the American Joint Committee on Cancer (AJCC) and the Union Internationale contre le Cancre (UICC). This article traces the developments in risk assessment that have lead to this consensus, which would prospectively allow comparison among future clinical trials. |
| Keywords: | review; cancer recurrence; cisplatin; cancer risk; cancer staging; metastasis; carcinoembryonic antigen; tumor markers, biological; risk factors; tumor marker; risk assessment; risk; cancer invasion; testicular neoplasms; lactate dehydrogenase; testis cancer; germ cell tumor; seminoma; chorionic gonadotropin beta subunit; alpha fetoprotein; chorionic gonadotropin; follitropin; luteinizing hormone; humans; prognosis; human; male; priority journal |
| Journal Title: | Urologic Clinics of North America |
| Volume: | 25 |
| Issue: | 3 |
| ISSN: | 0094-0143 |
| Publisher: | W.B. Saunders Co-Elsevier Inc. |
| Date Published: | 1998-08-01 |
| Start Page: | 389 |
| End Page: | 395 |
| Language: | English |
| PUBMED: | 9728209 |
| PROVIDER: | scopus |
| DOI: | 10.1016/S0094-0143(05)70029-X |
| DOI/URL: | |
| Notes: | Review -- Export Date: 12 December 2016 -- Source: Scopus |
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