The efficacy of IL-3, SCF, IL-6, and IL-11 in treating thrombocytopenia Journal Article
| Authors: | Maslak, P.; Nimer, S. D. |
| Article Title: | The efficacy of IL-3, SCF, IL-6, and IL-11 in treating thrombocytopenia |
| Abstract: | Suppression of normal hematopoiesis is a frequent complication of cancer or its treatment. The basis for dose-intensified cancer therapy in the 1990s was the discovery that hematopoietic growth factors and peripheral blood progenitor cell infusions can ameliorate some of its associated hematologic toxicities. Both granulocyte colony-stimulating factor and granulocyte macrophage colony-stimulating factor accelerate neutrophil recovery after chemotherapy and can mobilize peripheral blood progenitor cells for use in autologous or allogeneic transplantation. Unfortunately, the duration and severity of chemotherapy-induced thrombocytopenia is unaffected by the use of these myeloid growth factors. During the last 5 years, the activities of a variety of potential platelet or megakaryocyte-stimulating factors have been determined in clinical trials. The results of these studies are described. |
| Keywords: | human tissue; human cell; clinical trial; neutropenia; review; drug efficacy; stem cell factor; phase 2 clinical trial; bone marrow suppression; thrombocytopenia; myalgia; fever; immunotherapy; drug mechanism; recombinant proteins; interleukin-6; headache; phase 1 clinical trial; recombinant interleukin 11; recombinant interleukin 3; recombinant stem cell factor; interleukin-11; interleukin-3; growth stimulation; humans; human; priority journal; recombinant interleukin 6 |
| Journal Title: | Seminars in Hematology |
| Volume: | 35 |
| Issue: | 3 |
| ISSN: | 0037-1963 |
| Publisher: | W.B. Saunders Co-Elsevier Inc. |
| Date Published: | 1998-07-01 |
| Start Page: | 253 |
| End Page: | 260 |
| Language: | English |
| PUBMED: | 9685171 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 12 December 2016 -- Source: Scopus |
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