New chemotherapy regimens for metastatic bladder cancer Journal Article
| Authors: | Dodd, P. M.; Bajorin, D. F. |
| Article Title: | New chemotherapy regimens for metastatic bladder cancer |
| Abstract: | M-VAC remains the standard of care for metastatic transitional cell carcinoma (TCC), but its limitations include significant toxicity and infrequent durable disease-free survival. Recent investigation has focused on the identification of novel chemotherapeutics with single-agent activity in metastatic TCC and on their incorporation into more active combination regimens. Paclitaxel, gemcitabine and ifosfamide are among the most active new agents. Numerous phase II trials of novel combinations have yielded promising preliminary results. Longer follow-up and results from randomized trials will be necessary to determine the impact of newer chemotherapy regimens on survival. |
| Keywords: | survival rate; clinical trial; review; cisplatin; doxorubicin; fluorouracil; gemcitabine; paclitaxel; chemotherapy; cytarabine; methotrexate; carboplatin; metastasis; cyclophosphamide; bladder cancer; ifosfamide; vinblastine; docetaxel; taxane derivative; mesna; transitional cell carcinoma; meta analysis; pertussis vaccine; intramuscular drug administration; piritrexim; lobaplatin; gallium nitrate; human; priority journal |
| Journal Title: | Current Opinion in Urology |
| Volume: | 8 |
| Issue: | 5 |
| ISSN: | 0963-0643 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 1998-09-01 |
| Start Page: | 413 |
| End Page: | 418 |
| Language: | English |
| DOI: | 10.1097/00042307-199809000-00010 |
| PROVIDER: | scopus |
| PUBMED: | 17039022 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 12 December 2016 -- Source: Scopus |
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