Chemotherapy in gynecologic cancer Journal Article

  


Authors: Sabbatini, P.; Aghajanian, C.; Spriggs, D.
Article Title: Chemotherapy in gynecologic cancer
Abstract: The current standard for primary chemotherapy in patients with ovarian cancer consists of platinum and taxane combination treatment. The roles of the intraperitoneal delivery of agents, and of the multiple new agents with phase II activity, are currently under investigation. Many new agents and combinations warrant further testing in the primary treatment setting. Recent advances in the treatment of cervical cancer involve the selection of agents for chemoradiation in locally advanced disease, the role of combination versus single agent therapy in recurrent disease, and the identification of a new agent with limited activity in advanced disease. Ongoing trials in patients with endometrial cancer are attempting to improve therapy for advanced disease, and are exploring the role of adjuvant chemotherapy in patients with earlier disease stages.
Keywords: hydroxyurea; clinical trial; review; cancer recurrence; cisplatin; doxorubicin; fluorouracil; cancer combination chemotherapy; gemcitabine; paclitaxel; topotecan; neurotoxicity; endometrial neoplasms; endometrium cancer; ovarian neoplasms; carboplatin; ovary cancer; etoposide; blood toxicity; antineoplastic combined chemotherapy protocols; cyclophosphamide; melphalan; ifosfamide; irinotecan; genital neoplasms, female; uterine cervix cancer; altretamine; platinum; taxane derivative; uterine cervical neoplasms; granulocyte colony stimulating factor; intravenous drug administration; oral drug administration; intraperitoneal drug administration; interleukin 3; mitolactol; humans; human; female; priority journal
Journal Title: Current Opinion in Oncology
Volume: 10
Issue: 5
ISSN: 1040-8746
Publisher: Lippincott Williams & Wilkins  
Date Published: 1998-09-01
Start Page: 429
End Page: 433
Language: English
PUBMED: 9800113
PROVIDER: scopus
DOI: 10.1097/00001622-199809000-00010
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031789846&partnerID=40&md5=3b2bd481c856f3cc1bb6564bc80a138e
Notes: Review -- Export Date: 12 December 2016 -- Source: Scopus
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MSK Authors
  1. Paul J Sabbatini
    262 Sabbatini
  2. Carol A Aghajanian
    609 Aghajanian
  3. David R Spriggs
    325 Spriggs
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