Renal toxicities of novel agents used for treatment of multiple myeloma Journal Article
| Authors: | Wanchoo, R.; Abudayyeh, A.; Doshi, M.; Edeani, A.; Glezerman, I. G.; Monga, D.; Rosner, M.; Jhaveri, K. D. |
| Article Title: | Renal toxicities of novel agents used for treatment of multiple myeloma |
| Abstract: | Survival for patients with multiple myeloma has significantly improved in the last decade in large part due to the development of proteasome inhibitors and immunomodulatory drugs. These next generation agents with novel mechanisms of action as well as targeted therapies are being used both in the preclinical and clinical settings for patients with myeloma. These agents include monoclonal antibodies, deacetylase inhibitors, kinase inhibitors, agents affecting various signaling pathways, immune check point inhibitors, and other targeted therapies. In some cases, off target effects of these therapies can lead to unanticipated effects on the kidney, that can range from electrolyte disorders to AKI. In this review, we discuss the nephrotoxicities of novel agents currently in practice as well as in development for the treatment of myeloma. |
| Keywords: | dexamethasone; tuberous sclerosis; placebo-controlled trial; stem-cell transplantation; thrombotic microangiopathy; complex; acute kidney injury; lenalidomide plus dexamethasone; low-dose; kir; braf v600e mutation; acute interstitial nephritis; antibody iph2101 |
| Journal Title: | Clinical Journal of the American Society of Nephrology |
| Volume: | 12 |
| Issue: | 1 |
| ISSN: | 1555-9041 |
| Publisher: | American Society of Nephrology |
| Date Published: | 2017-01-01 |
| Start Page: | 176 |
| End Page: | 189 |
| Language: | English |
| ACCESSION: | WOS:000391416700022 |
| DOI: | 10.2215/cjn.06100616 |
| PROVIDER: | wos |
| PMCID: | PMC5220662 |
| PUBMED: | 27654928 |
| Notes: | Review -- Source: Wos |
