Pancreatic tumor motion on a single planning 4D-CT does not correlate with intrafraction tumor motion during treatment Journal Article
| Authors: | Minn, A. Y.; Schellenberg, D.; Maxim, P.; Suh, Y.; McKenna, S.; Cox, B.; Dieterich, S.; Xing, L.; Graves, E.; Goodman, K. A.; Chang, D.; Koong, A. C. |
| Article Title: | Pancreatic tumor motion on a single planning 4D-CT does not correlate with intrafraction tumor motion during treatment |
| Abstract: | PURPOSE: To quantify pancreas tumor motion on both a planning 4D-CT and during a single fraction treatment using the CyberKnife linear accelerator and Synchrony respiratory tracking software, and to investigate whether a single 4D-CT study is reliable for determining radiation treatment margins for patients with locally advanced pancreas cancer. METHODS AND MATERIALS: Twenty patients underwent fiducial placement, biphasic pancreatic protocol CT scan and 4D-CT scan in the treatment position while free-breathing. Patients were then treated with a single 25 Gy fraction of stereotactic body radiotherapy. Predicted pancreas motion in the superior-inferior (SI), left-right (LR), and anterior-posterior (AP) directions was calculated from the maximum inspiration and maximum expiration 4D-CT scan. For CyberKnife treatments, mean respiratory cycle motion and maximum respiratory cycle motion was determined in the SI, LR, and AP directions. RESULTS: The range of centroid movement based on 4D-CT in the SI, LR, and AP directions were 0.9 to 28.8 mm, 0.1 to 13.7 mm, and 0.2 to 7.6 mm, respectively. During CyberKnife treatment, in the SI direction, the mean motion of the centroid ranged from 0.5 to 12.7 mm. In the LR direction, the mean motion range was 0.4 to 9.4 mm. In the AP direction, the mean motion range was 0.6 to 5.5 mm. The maximum range of movement (mean) during CyberKnife treatment in the SI, LR, and AP directions were 4.5 to 48.8 mm (mean 20.8 mm), 1.5 to 41.3 mm (mean 11.3 mm), and 1.6 to 68.1 mm (mean 13.4 mm), respectively. Neither the maximum or mean motion correlated with the 4D-CT movement. CONCLUSIONS: There is substantial respiratory associated motion of pancreatic tumors. The 4D-CT planning scans cannot accurately predict the movement of pancreatic tumors during actual treatment on CyberKnife. © 2009 Lippincott Williams & Wilkins, Inc. |
| Keywords: | adult; clinical article; treatment outcome; aged; middle aged; retrospective studies; advanced cancer; cancer radiotherapy; pancreas cancer; preoperative care; radiation dose; pancreatic neoplasms; follow-up studies; computer assisted tomography; cohort studies; radiotherapy dosage; tomography, x-ray computed; risk assessment; imaging, three-dimensional; pancreas tumor; radiosurgery; predictive value of tests; radiation therapy; radiotherapy planning, computer-assisted; stereotactic body radiation therapy; motion; computer program; igrt; linear accelerator; cyberknife; sbrt; breathing pattern; four dimensional computer assisted tomography |
| Journal Title: | American Journal of Clinical Oncology |
| Volume: | 32 |
| Issue: | 4 |
| ISSN: | 0277-3732 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2009-08-01 |
| Start Page: | 364 |
| End Page: | 368 |
| Language: | English |
| DOI: | 10.1097/COC.0b013e31818da9e0 |
| PUBMED: | 19398901 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 30 November 2010" - "CODEN: AJCOD" - "Source: Scopus" |
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