Novel treatment targets in sarcoma: More than just the GIST Journal Article

  


Authors: Shoushtari, A. N.; Van Tine, B. A.; Schwartz, G. K.
Article Title: Novel treatment targets in sarcoma: More than just the GIST
Abstract: Sarcomas are rare tumors comprising a heterogeneous group of more than 50 histologic subtypes, the majority of which do not respond well to cytotoxic chemotherapy. This has fueled research into the distinct molecular mechanisms of tumorigenesis and disease progression for various sarcoma subtypes. Gastrointestinal stromal tumors and liposarcomas are presented as paradigms of molecular classification that have led to the rational development of novel therapeutic strategies for those tumors. Recent advances in understanding of growth signaling pathways, metabolic reprogramming, and immune therapy have identified new treatment targets for many sarcomas. These investigations will form the foundation for further improvements in our ability to care for patients with these tumors and may offer clinical insights into a wide range of other tumors.
Keywords: osteosarcoma; signal transduction; treatment outcome; bone neoplasms; genetics; mutation; antineoplastic agents; antineoplastic agent; phenotype; animal; metabolism; animals; gastrointestinal stromal tumors; genetic predisposition to disease; tumor markers, biological; pathology; tumor marker; sarcoma; gastrointestinal neoplasms; immunology; immunotherapy; genetic predisposition; chondrosarcoma; liposarcoma; adverse effects; molecularly targeted therapy; molecular targeted therapy; procedures; drug effects; humans; human
Journal Title: American Society of Clinical Oncology Educational Book
Volume: 34
ISSN: 1548-8756
Publisher: American Society of Clinical Oncology  
Date Published: 2014-01-01
Start Page: e488
End Page: e495
Language: English
DOI: 10.14694/EdBook_AM.2014.34.e488
PUBMED: 24857144
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-84942203275&doi=10.14694%2fEdBook_AM.2014.34.e488&partnerID=40&md5=4527ae582b51029f74607fc93afcaee8
Notes: Review -- Export Date: 25 January 2017 -- Source: Scopus
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MSK Authors
  1. Gary Schwartz
    385 Schwartz
  2. Alexander Noor Shoushtari
    244 Shoushtari
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