Rationale and design of the chronic GVHD cohort study: Improving outcomes assessment in chronic GVHD Journal Article
| Authors: | Lee, S. J.; Flowers, M. E. D.; Martin, P. J.; Carpenter, P.; Hansen, J.; Chai, X.; Kurland, B.; Storer, B.; Arai, S.; Johnston, L.; Miklos, D.; Weisdorf, D.; Arora, M.; Majhail, N.; Cutler, C.; Jagasia, M.; Palmer, J.; Pidala, J.; Westervelt, P.; Pusic, I.; Giralt, S.; Goldberg, J.; Couriel, D.; Kitko, C.; Pavletic, S. Z.; Vogelsang, G. B.; Gilman, A.; Schultz, K. |
| Article Title: | Rationale and design of the chronic GVHD cohort study: Improving outcomes assessment in chronic GVHD |
| Abstract: | In 2005, the National Institutes of Health sponsored a Consensus Development Project on Criteria for Clinical Trials in chronic graft-versus-host (cGVHD) to achieve consensus about key elements of cGVHD research, including definitions for diagnosis, severity scoring, and response measures. To test these proposed definitions, a multicenter prospective cohort study of people with cGVHD is ongoing. This study will evaluate the performance of proposed prognostic factors, measures of disease activity, and surrogate endpoints for therapeutic response. Data are collected at 6-month intervals in a heterogeneous population of patients reflecting modern transplant techniques and posttransplantation clinical management (target enrollment 672 with cGVHD from I 0 transplantation centers). This report describes the rationale, design, and methods of the cGVHD cohort study, and invites other investigators to collaborate with the Consortium to analyze data or specimens. Biol Blood Marrow Transplant 17: 1114-1120 (2011) (C) 2011 American Society for Blood and Mal-row Transplantation. |
| Keywords: | transplantation; outcomes research; health; cell transplantation; clinical-trials; versus-host-disease; bone-marrow-transplantation; criteria; working; comorbidity index; chronic graft-versus-host disease; allogeneic hematopoietic cell; observational clinical study; consensus development project; group-report; chronic graft |
| Journal Title: | Biology of Blood and Marrow Transplantation |
| Volume: | 17 |
| Issue: | 8 |
| ISSN: | 1083-8791 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2011-08-01 |
| Start Page: | 1114 |
| End Page: | 1120 |
| Language: | English |
| DOI: | 10.1016/j.bbmt.2011.05.007 |
| ACCESSION: | WOS:000293429600003 |
| PROVIDER: | wos |
| PUBMED: | 21664473 |
| PMCID: | PMC4016312 |
| Notes: | --- - Editorial Material - "Source: Wos" |
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