Translocation-Related Sarcomas Journal Article
| Authors: | Mertens, F.; Antonescu, C. R.; Hohenberger, P.; Ladanyi, M.; Modena, P.; D'Incalci, M.; Casali, P. G.; Aglietta, M.; Alvegård, T. |
| Article Title: | Translocation-Related Sarcomas |
| Abstract: | Sarcomas with chromosomal translocations represent only about one fourth of sarcoma diagnoses. However, like gastrointestinal stromal tumor (GIST), with its characteristic KIT or PDGFRA mutations, they are particularly interesting since they provide specific biological insights and mechanisms of action that may have an impact upon prognosis or therapy. These are mechanisms we are just beginning to exploit. In this section we will review the biology and clinical impact of translocation-associated sarcomas and review the clinical findings that have made a recent impact upon patients with these diverse diagnoses. © 2009. |
| Keywords: | cancer chemotherapy; cancer survival; unclassified drug; gene mutation; clinical feature; clinical trial; histopathology; neutropenia; side effect; cancer grading; gastrointestinal stromal tumor; imatinib; stem cell factor; metastasis; reverse transcription polymerase chain reaction; platelet derived growth factor receptor; cancer research; aminotransferase blood level; ewing sarcoma; sarcoma; chromosome aberration; fluorescence in situ hybridization; gene fusion; soft tissue sarcoma; chromosome translocation; translocation, genetic; bcr abl protein; trabectedin; dermatofibroma; leiomyosarcoma; rhabdomyosarcoma; synovial sarcoma; anthracycline; sarcoma, ewing's; drug sensitivity; neuroectoderm tumor; drug binding; liposarcoma; clear cell sarcoma; 5 (2,6 dichlorobenzylsulfonyl) 3 [3,5 dimethyl 4 [2 (1 pyrrolidinylmethyl) 1 pyrrolidinylcarbonyl] 1h pyrrol 2 ylmethylene] 1,3 dihydro 2h indol 2 one; platelet derived growth factor receptor a; neuroectodermal tumors, primitive |
| Journal Title: | Seminars in Oncology |
| Volume: | 36 |
| Issue: | 4 |
| ISSN: | 0093-7754 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2009-08-01 |
| Start Page: | 312 |
| End Page: | 323 |
| Language: | English |
| DOI: | 10.1053/j.seminoncol.2009.06.004 |
| PUBMED: | 19664492 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 2" - "Export Date: 30 November 2010" - "CODEN: SOLGA" - "Source: Scopus" |
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