Genomics of primary chemoresistance and remission induction failure in paediatric and adult acute myeloid leukaemia Journal Article

   

Authors:	Brown, F. C.; Cifani, P.; Drill, E.; He, J.; Still, E.; Zhong, S.; Balasubramanian, S.; Pavlick, D.; Yilmazel, B.; Knapp, K. M.; Alonzo, T. A.; Meshinchi, S.; Stone, R. M.; Kornblau, S. M.; Marcucci, G.; Gamis, A. S.; Byrd, J. C.; Gonen, M.; Levine, R. L.; Kentsis, A.
Article Title:	Genomics of primary chemoresistance and remission induction failure in paediatric and adult acute myeloid leukaemia
Abstract:	Cure rates of children and adults with acute myeloid leukaemia (AML) remain unsatisfactory partly due to chemotherapy resistance. We investigated the genetic basis of AML in 107 primary cases by sequencing 670 genes mutated in haematological malignancies. SETBP1, ASXL1 and RELN mutations were significantly associated with primary chemoresistance. We identified genomic alterations not previously described in AML, together with distinct genes that were significantly overexpressed in therapy-resistant AML. Defined gene mutations were sufficient to explain primary induction failure in only a minority of cases. Thus, additional genetic or molecular mechanisms must cause primary chemoresistance in paediatric and adult AML. © 2016 John Wiley & Sons Ltd
Keywords:	induction failure; cytogenetically normal acute myeloid leukaemia; paediatric leukaemia; primary chemoresistance; targeted deep sequencing genomics
Journal Title:	British Journal of Haematology
Volume:	176
Issue:	1
ISSN:	0007-1048
Publisher:	John Wiley & Sons
Date Published:	2017-01-01
Start Page:	86
End Page:	91
Language:	English
DOI:	10.1111/bjh.14413
PROVIDER:	scopus
PMCID:	PMC5177472
PUBMED:	27766616
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84995469181&doi=10.1111%2fbjh.14413&partnerID=40&md5=8603924ace98664fbba0862b9d0b846e
Notes:	Article -- Export Date: 3 January 2017 -- Source: Scopus

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