Toward a potential total synthesis of gelsemine: A regioselective hydroboration directed by a remote olefin Journal Article
| Authors: | Ng, F.; Chiu, P.; Danishefsky, S. J. |
| Article Title: | Toward a potential total synthesis of gelsemine: A regioselective hydroboration directed by a remote olefin |
| Abstract: | Hydroboration of bicyclo[3.2.1]octa-2,6-diene derivatives occurred exclusively on one olefin, and within this olefin, remarkable regioselective addition of boron to one carbon terminus was observed. This regioselectivity was significantly improved with more electrophilic hydroborating agents. The regioselectivity is attributed to the directive effect of a remote olefin. |
| Keywords: | controlled study; unclassified drug; nonhuman; united states; drug synthesis; alkene; hydroboration; gelsemine; article; oxetane derivative |
| Journal Title: | Tetrahedron Letters |
| Volume: | 39 |
| Issue: | 8 |
| ISSN: | 0040-4039 |
| Publisher: | Pergamon-Elsevier Science Ltd |
| Date Published: | 1998-02-19 |
| Start Page: | 767 |
| End Page: | 770 |
| Language: | English |
| DOI: | 10.1016/s0040-4039(97)10621-9 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 12 December 2016 -- Source: Scopus |
