Role of PML in cell growth and the retinoic acid pathway Journal Article

  


Authors: Wang, Z. G.; Delva, L.; Gaboli, M.; Rivi, R.; Giorgio, M.; Cordon-Cardo, C.; Grosveld, F.; Pandolfi, P. P.
Article Title: Role of PML in cell growth and the retinoic acid pathway
Abstract: The PML gene is fused to the retinoic acid receptor α (RARα) gene in chromosomal translocations associated with acute promyelocytic leukemia (APL). Ablation of murine PML protein by homologous recombination revealed that PML regulates hemopoietic differentiation and controls cell growth and tumorigenesis. PML was essential for the tumor-growth-suppressive activity of retinoic acid (RA) and for its ability to induce terminal myeloid differentiation of precursor cells. PML was needed for the RA-dependent transactivation of the p21(WAF1/GIP1 gene, which regulates cell cycle progression and cellular differentiation. These results indicate that PML is a critical component of the RA pathway and that disruption of its activity by the PML-RARα fusion protein may be important in an APL pathogenesis.
Keywords: unclassified drug; human cell; pathogenesis; animals; mice; cells, cultured; gene targeting; cell division; apoptosis; neoplasm proteins; cell differentiation; transcription factors; cell transformation, neoplastic; nuclear proteins; gene expression regulation; tumor suppressor gene; leukemia, promyelocytic, acute; tumor suppressor proteins; acute myeloblastic leukemia; gene fusion; oncogene proteins, fusion; transactivation; hematopoietic stem cells; murinae; neoplasms, experimental; fibroblasts; chromosome translocation; hematopoiesis; cyclin-dependent kinase inhibitor p21; monocytes; cyclins; protein p21; retinoic acid; receptor gene; promyelocytic leukemia protein; retinoic acid receptor alpha; tretinoin; granulocytes; trans-activation (genetics); concanavalin a; human; male; female; priority journal; article; dimethylbenz[a]anthracene
Journal Title: Science
Volume: 279
Issue: 5356
ISSN: 0036-8075
Publisher: American Association for the Advancement of Science  
Date Published: 1998-03-06
Start Page: 1547
End Page: 1551
Language: English
DOI: 10.1126/science.279.5356.1547
PUBMED: 9488655
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0000237552&doi=10.1126%2fscience.279.5356.1547&partnerID=40&md5=d6638926ecd84144898ba416106d145b
Notes: Article -- Export Date: 12 December 2016 -- Source: Scopus
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MSK Authors
  1. Mirella P Gaboli
    19 Gaboli
  2. Pier Paolo Pandolfi Derinaldis
    353 Pandolfi Derinaldis
  3. Carlos Cordon-Cardo
    612 Cordon-Cardo
  4. Roberta Rivi
    25 Rivi
  5. Zhu-Gang Wang
    17 Wang
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