Primary sarcomas of the mediastinum: Results of therapy Journal Article
| Authors: | Burt, M.; Ihde, J. K.; Hajdu, S. I.; Smith, J. W.; Bains, M. S.; Downey, R.; Martini, N.; Rusch, V. W.; Ginsberg, R. J. |
| Article Title: | Primary sarcomas of the mediastinum: Results of therapy |
| Abstract: | Primary sarcomas of the mediastinum are rare, and data concerning treatment and results of therapy are sparse. Objective: To assess presentation, management, prognostic factors, and survival in mediastinal sarcomas. Methods: We reviewed our experience with 47 patients with the diagnosis of primary sarcoma of the mediastinum. Data were collected from a computerized institutional database and medical records. Survival was analyzed by Kaplan-Meier method and comparisons of survival by log rank test. Results: The median age of 47 patients with mediastinal sarcoma was 39 years (range 2.5 to 69 years), with a male/female ratio of 1.6. The most common complaints were chest/shoulder pain (38%) and dyspnea (23%). The most common tumor types were malignant peripheral nerve tumor (26%), spindle cell sarcoma (15%), leiomyosarcoma (9%), and liposarcoma (9%). Operation was the primary treatment modality in 72% of cases (n = 34); 22 sarcomas (47%) were completely resected. The overall 5-year survival was 32%. High-grade lesions had a significantly decreased survival (5-year survival = 27%) compared with low-grade tumors (5-year survival = 66%) (p = 0.05). The overwhelming factor determining survival was the ability to completely resect the tumors (5-year survival 49% for complete resection; 3-year survival 18% for incomplete or no resection) (p = 0.0016). Despite complete resection, local recurrence occurred in 64% of cases. Conclusion: Because the overall survival for patients with mediastinal sarcomas is 32% and the local recurrence is 64% for tumors completely resected, aggressive adjuvant therapy should continue to be systematically explored. |
| Keywords: | adolescent; adult; cancer chemotherapy; cancer survival; child; clinical article; treatment outcome; aged; child, preschool; middle aged; survival analysis; cancer surgery; retrospective studies; cancer recurrence; cancer radiotherapy; combined modality therapy; metastasis; neoplasm recurrence, local; dyspnea; sarcoma; postoperative complications; thorax pain; neoplasm metastasis; leiomyosarcoma; spindle cell sarcoma; mediastinum tumor; mediastinal neoplasms; peripheral nerve tumor; liposarcoma; shoulder pain; humans; human; male; female; priority journal; article |
| Journal Title: | Journal of Thoracic and Cardiovascular Surgery |
| Volume: | 115 |
| Issue: | 3 |
| ISSN: | 0022-5223 |
| Publisher: | Mosby Elsevier |
| Date Published: | 1998-03-01 |
| Start Page: | 671 |
| End Page: | 680 |
| Language: | English |
| DOI: | 10.1016/s0022-5223(98)70333-2 |
| PUBMED: | 9535456 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 12 December 2016 -- Source: Scopus |
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