Bone mineral density in young adult survivors of childhood cancer Journal Article
| Authors: | Aisenberg, J.; Hsieh, K.; Kalaitzoglou, G.; Whittam, E.; Heller, G.; Schneider, R.; Sklar, C. |
| Article Title: | Bone mineral density in young adult survivors of childhood cancer |
| Abstract: | Purpose: Childhood cancer and its treatment can affect normal bone accretion. In this study, bone mineral density (BMD) in young adult survivors of childhood cancer is assessed to determine what cancer-related factors, patient characteristics, or treatment-related complications correlate with reductions in BMD. Patients and Methods: The study population consisted of 40 (24 women) long-term survivors of childhood cancer treated at the Memorial Sloan-Kettering Cancer Center for a solid tumor (n = 16), lymphoma (n = 14), or acute leukemia (n = 10) at a mean age of 12.7 ±0.96 years and evaluated at a mean age of 25.8 ± 0.7 years. Dual energy X-ray absorptiometry was used to determine BMD of the lumbar spine, femoral neck, and total body and single photon absorptiometry was used to determine BMD of the distal radius. Results: The mean BMD standard deviation score (SDS) for the patients was significantly reduced compared to controls at the distal radius (-1.57 ± 0.18, p = 0.0001), femoral neck (-0.68 0.20, p = 0.00014), and total body (- 0.33 ± 0.15, p = 0.03) but not at the lumbar spine (-0.22 ± 0.22, p = 0.33). Univariate analysis revealed that gonadal dysfunction (i.e., estrogen or testosterone insufficiency) (p = 0.018) was the only variable that correlated with a reduced BMD. Conclusion: Young adult survivors of childhood cancer have reduced BMD. Because age at study coincides with the normal age of attainment of peak bone mass and peak bone mass is a major determinant of BMD later in life, many of these patients are at increased risk for osteoporosis and fractures. |
| Keywords: | adolescent; adult; cancer survival; child; clinical article; fracture; neoplasms; bone density; childhood cancer; gonad dysfunction; gonadal disorders; survivors; bone mass; femur; dual energy x ray absorptiometry; lumbar vertebrae; bone mineral density; lumbar spine; radius; cytoarchitecture; hormone deficiency; bone mineral; femur neck; humans; human; male; female; priority journal; article; gonadal dysfunction; densitometry, x-ray |
| Journal Title: | Journal of Pediatric Hematology/Oncology |
| Volume: | 20 |
| Issue: | 3 |
| ISSN: | 1077-4114 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 1998-05-01 |
| Start Page: | 241 |
| End Page: | 245 |
| Language: | English |
| DOI: | 10.1097/00043426-199805000-00010 |
| PUBMED: | 9628436 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 12 December 2016 -- Source: Scopus |
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