Long-term survival in primary CNS lymphoma Journal Article
| Authors: | Abrey, L. E.; DeAngelis, L. M.; Yahalom, J. |
| Article Title: | Long-term survival in primary CNS lymphoma |
| Abstract: | Purpose: We have previously reported on 31 patients with primary CNS lymphoma (PCNSL) treated between 1986 and 1992 with methotrexate (MTX), cranial radiotherapy (RT), and high-dose cytarabine who remained free of disease longer than historical controls. Patients and Methods: We performed a follow-up analysis of our original cohort and now report their long-term survival and late treatment-related toxicity. Results: The median cause- specific survival was 42 months, with a five-year survival of 22.3% compared with 3% to 4% in historical controls treated with RT alone. Age less than 50 years at diagnosis was a significant prognostic factor for survival (P = .01). Median disease-free survival was 40.3 months; 15 patients relapsed, all but one in the CNS. Late treatment-related toxicity was observed in nearly one third of patients and those more than 60 years of age were at substantially higher risk (P < .0001). Conclusion: Combined modality therapy for PCNSL has improved survival, but relapse is common and late neurologic toxicity is a significant complication. Although this approach is highly effective for younger patients, efficacious but less neurotoxic regimens need to be developed for older patients. |
| Keywords: | adult; cancer survival; clinical article; treatment outcome; aged; middle aged; survival analysis; prednisone; cancer recurrence; doxorubicin; multimodality cancer therapy; cancer radiotherapy; radiation dose; combined modality therapy; cytarabine; methotrexate; neurotoxicity; follow-up studies; antineoplastic combined chemotherapy protocols; cyclophosphamide; vincristine; cranial irradiation; central nervous system neoplasms; folinic acid; lymphoma; remission induction; aging; onset age; brain lymphoma; humans; prognosis; human; male; female; priority journal; article |
| Journal Title: | Journal of Clinical Oncology |
| Volume: | 16 |
| Issue: | 3 |
| ISSN: | 0732-183X |
| Publisher: | American Society of Clinical Oncology |
| Date Published: | 1998-03-01 |
| Start Page: | 859 |
| End Page: | 863 |
| Language: | English |
| PUBMED: | 9508166 |
| PROVIDER: | scopus |
| DOI: | 10.1200/JCO.1998.16.3.859 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 12 December 2016 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
-
625Yahalom -
576De Angelis -
278Abrey
Related MSK Work