Long term results of primary radiotherapy with/without neck dissection for squamous cell cancer of the base of tongue Journal Article
| Authors: | Harrison, L. B.; Lee, H. J.; Pfister, D. G.; Kraus, D. H.; White, C.; Raben, A.; Zelefsky, M. J.; Strong, E. W.; Shah, J. P. |
| Article Title: | Long term results of primary radiotherapy with/without neck dissection for squamous cell cancer of the base of tongue |
| Abstract: | Background. There are several management options for patients with squamous cell cancer of the base of tongue. We have had an interest in using primary radiotherapy with or without neck dissection, in an effort to provide optimal oncologic as well as functional outcomes. Methods. From 1981 to 1995, 68 patients with primary squamous cell cancer of the base of tongue were managed with primary radiotherapy, with neck dissection added for those who were initially seen with palpable lymph node metastases. Ages ranged from 35 to 77 years (median age, 55 years). There were 59 men and 9 women. T stage distribution was: T1, 17; T2, 32; T3, 17; T4, 2. Fifty-eight patients (85%) were initially seen with nodal metastases. Initial treatment generally involved external-beam radiotherapy (EBRT) to the primary site and upper neck (54 Gy) and to the low neck (50 Gy). A 192-lr brachytherapy boost (20-30 Gy) to the base of tongue was done about 3 weeks later, at the same anesthesia used for the neck dissection. All patients had temporary tracheostomy. Follow-up ranged from 1 month to 151 months (median, 36 months). Nine patients received neoadjuvant chemotherapy as part of a larynx-preservation protocol. Results. Actuarial 5- and 10-year local control is 89% and 89%, distant metastasis free survival is 91% and 76%, disease-free survival is 80% and 67%, and overall survival is 86% and 52%, respectively. Complications occurred in 16%. Conclusions: Our long term data clearly demonstrate that primary radiotherapy produces excellent oncologic outcomes. |
| Keywords: | adult; cancer survival; controlled study; treatment outcome; aged; middle aged; survival analysis; cancer surgery; retrospective studies; major clinical study; clinical trial; neck dissection; squamous cell carcinoma; cancer radiotherapy; combined modality therapy; cancer staging; lymph node metastasis; antineoplastic agent; lymphatic metastasis; lymph node excision; treatment indication; radiotherapy dosage; radiotherapy; clinical protocol; adjuvant chemotherapy; brachytherapy; tongue neoplasms; tongue carcinoma; iridium 192; neoplasms, squamous cell; tracheotomy; humans; human; male; female; priority journal; article; base of tongue |
| Journal Title: | Head & Neck |
| Volume: | 20 |
| Issue: | 8 |
| ISSN: | 1043-3074 |
| Publisher: | John Wiley & Sons, Inc. |
| Date Published: | 1998-12-01 |
| Start Page: | 668 |
| End Page: | 673 |
| Language: | English |
| DOI: | 10.1002/(sici)1097-0347(199812)20:8<668::aid-hed2>3.0.co;2-9 |
| PUBMED: | 9790286 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 12 December 2016 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work