Palliative benefit of external-beam radiation in the management of platinum refractory epithelial ovarian carcinoma Journal Article
| Authors: | Gelblum, D.; Mychalczak, B.; Almadrones, L.; Spriggs, D.; Barakat, R. |
| Article Title: | Palliative benefit of external-beam radiation in the management of platinum refractory epithelial ovarian carcinoma |
| Abstract: | In vitro studies and clinical experience have suggested that patients with platinum-refractory epithelial ovarian carcinoma exhibit cross- resistance to radiation. Salvage with radiation in these patients is rare. However, radiation is often utilized to palliate symptoms caused by these chemotherapy-resistant tumors. Forty-seven patients with platinum-refractory epithelial ovarian carcinoma were referred for palliative radiation and 33 (70%) were evaluable for response. One to four regimens of platinum-based chemotherapy (median 2.7) were given to each patient prior to radiation therapy. Of the 33 evaluable patients, 23 (69.7%) had a complete resolution of symptoms after radiation, 8 (24%) bad a partial resolution, and 2 were unassessable because of unrelated medical complications. The median duration of response was 11 months (range 1-86) and closely approximated their survival. Thirteen of 33 patients (39%) obtained relief of symptoms for greater than 12 months, with 10 of 33 (30%) having symptoms controlled for 6 to 12 months. In only 10 patients (30%) was the duration of palliation less than or equal to 6 months. Four patients required reirradiation to the same area for recurrence of their symptom. External-beam radiation therapy can provide effective and durable palliation of symptoms in platinum-refractory epithelial ovarian carcinoma patients. |
| Keywords: | adult; clinical article; aged; aged, 80 and over; middle aged; survival rate; retrospective studies; salvage therapy; cisplatin; antineoplastic agents; cancer radiotherapy; combined modality therapy; cancer palliative therapy; palliative care; ovarian neoplasms; recurrence; cancer regression; carcinoma; ovary carcinoma; beam therapy; humans; human; female; priority journal; article |
| Journal Title: | Gynecologic Oncology |
| Volume: | 69 |
| Issue: | 1 |
| ISSN: | 0090-8258 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1998-04-01 |
| Start Page: | 36 |
| End Page: | 41 |
| Language: | English |
| DOI: | 10.1006/gyno.1998.4934 |
| PUBMED: | 9570996 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 12 December 2016 -- Source: Scopus |
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97Mychalczak -
629Barakat -
228Gelblum -
325Spriggs -
72Cassidy
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