Nonsyntenic amplification of MYC with CDK4 and MDM2 in a malignant mixed tumor of salivary gland Journal Article

  


Authors: Rao, P. H.; Murty, V. V. V. S.; Louie, D. C.; Chaganti, R. S. K.
Article Title: Nonsyntenic amplification of MYC with CDK4 and MDM2 in a malignant mixed tumor of salivary gland
Abstract: Karyotypic analysis of a metastotic malignant mixed tumor of the salivary gland revealed the presence of double minute chromosomes (drain), indicative of gene amplification. Comparative genomic hybridization analysis of DNA extracted from the primary and a renal metastasis indicated overt amplification of DNA sequences derived from 8q23-24 and 12q13-15 regions. Subsequent Southern blot analysis of tumor DNA from the metastasis with the use of probes previously mapped to those regions indicated amplification of MYC at 8q23-24 and CDK4 and MDM2 at 12q13-15. Fluorescence in situ hybridization of differentially labeled MYC and MDM2 genes hybridized to tumor metaphase chromosomes revealed an independent nonsyntenic amplification of MYC and MDM2 on dmin in this tumor.
Keywords: adult; controlled study; human tissue; human cell; proto-oncogene proteins; case report; in situ hybridization, fluorescence; gene amplification; chromosomes, human, pair 8; nuclear proteins; fluorescence in situ hybridization; dna; genes, myc; mixed tumor; dna sequence; salivary gland tumor; salivary gland neoplasms; cyclin-dependent kinases; chromosome analysis; karyotype; kidney metastasis; chromosome 12q; oncogene myc; proto-oncogene proteins c-mdm2; chromosome 8q; cyclin-dependent kinase 4; mixed tumor, malignant; southern blotting; chromosomes, human, pair 12; humans; human; female; priority journal; article; double minute chromosome
Journal Title: Cancer Genetics and Cytogenetics
Volume: 105
Issue: 2
ISSN: 0165-4608
Publisher: Elsevier Science, Inc.  
Date Published: 1998-09-01
Start Page: 160
End Page: 163
Language: English
DOI: 10.1016/s0165-4608(98)00013-2
PUBMED: 9723034
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032171663&doi=10.1016%2fS0165-4608%2898%2900013-2&partnerID=40&md5=b87dc6e27a5077b5d2e56712a4da281b
Notes: Article -- Export Date: 12 December 2016 -- Source: Scopus
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MSK Authors
  1. Pulivarth H Rao
    66 Rao
  2. Diane C Louie
    52 Louie
  3. Raju S K Chaganti
    391 Chaganti
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