Structure and function of the insulin-like growth factor I receptor Journal Article

  


Author: Sepp-Lorenzino, L.
Article Title: Structure and function of the insulin-like growth factor I receptor
Abstract: Insulin-like growth factors I and II (IGF-I, IGF-II) were originally identified as potent mitogens and as the mediators of growth hormone action. Besides being mitogenic, however, these polypeptide growth factors play a crucial role in cell survival, and contribute to transformation and to maintenance of the malignant phenotype. Here we will discuss signaling by the IGFs, focusing specifically on the structure and function of the IGF-I receptor and the domains of this receptor responsible for distinct IGF functions: mitogenesis, transformation, and protection from apoptosis. We will also compare the structural domains of the related but functionally distinct receptor for insulin.
Keywords: signal transduction; protein domain; phenotype; animals; cell survival; apoptosis; breast cancer; mitogenesis; structure-activity relationship; growth hormone; somatomedin c receptor; receptor, igf type 1; cell transformation; cancer cell; regulation; somatomedin c; protein structure; somatomedin b; mitogenic agent; structure; insulin receptor; humans; human; priority journal; article; igf-i receptor; insulin-like growth factors (igfs)
Journal Title: Breast Cancer Research and Treatment
Volume: 47
Issue: 3
ISSN: 0167-6806
Publisher: Springer  
Date Published: 1998-02-01
Start Page: 235
End Page: 253
Language: English
DOI: 10.1023/a:1005955017615
PUBMED: 9516079
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031965186&doi=10.1023%2fA%3a1005955017615&partnerID=40&md5=ba8b7e232f274dea7c828691965ea0a2
Notes: Article -- Export Date: 12 December 2016 -- Source: Scopus
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MSK Authors
  1. Laura Sepp-Lorenzino
    40 Sepp-Lorenzino
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