Malignant glioma: Who benefits from adjuvant chemotherapy? Journal Article
| Authors: | DeAngelis, L. M.; Burger, P. C.; Green, S. B.; Cairncross, J. G. |
| Article Title: | Malignant glioma: Who benefits from adjuvant chemotherapy? |
| Abstract: | We combined two randomized prospective Brain Tumor Study Group data sets to analyze the effects of prognostic factors on survival by treatment group. Adjuvant chemotherapy increased long-term survival regardless of prognostic factors. Pathological review revealed that oligodendrogliomas were overrepresented among long-term survivors independent of therapy. Prognostic factors do not predict benefit from adjuvant nitrosourea in malignant gliomas, and long-term survival with chemotherapy is not explained by oligodendroglial tumors. |
| Keywords: | adult; cancer survival; aged; middle aged; survival analysis; major clinical study; cancer adjuvant therapy; chemotherapy, adjuvant; combined modality therapy; glioma; brain neoplasms; prospective studies; cancer mortality; carmustine; randomized controlled trials; glioblastoma; antineoplastic agents, alkylating; oligodendroglioma; nitrosourea derivative; humans; prognosis; human; priority journal; article |
| Journal Title: | Annals of Neurology |
| Volume: | 44 |
| Issue: | 4 |
| ISSN: | 0364-5134 |
| Publisher: | Wiley Blackwell |
| Date Published: | 1998-10-01 |
| Start Page: | 691 |
| End Page: | 695 |
| Language: | English |
| DOI: | 10.1002/ana.410440418 |
| PUBMED: | 9778271 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 12 December 2016 -- Source: Scopus |
