Disparity of isoflurane effects on left and right ventricular afterload and hydraulic power generation in swine Journal Article


Authors: Heerdt, P. M.; Gandhi, C. D.; Dickstein, M. L.
Article Title: Disparity of isoflurane effects on left and right ventricular afterload and hydraulic power generation in swine
Abstract: The interaction between myocardial and vascular effects of anesthetics has a potential impact on how these drugs influence performance of the heart. Most studies have focused on volatile anesthetic effects on the left ventricle (LV) and systemic circulation. Whether the right ventricle (RV) and pulmonary circulation respond in a similar fashion, however, is unclear. In the present study, we therefore examined the dose-related effects of isoflurane on LV and RV contractility and total afterload and related changes to simultaneous effects on the hydraulic power generated by each chamber. Two groups of swine were studied: one received no additional treatment before isoflurane (ISO, n = 6), and the other received hexamethonium, atropine, and propranolol to produce autonomic blockade before isoflurane administration (ISO+AB, n = 4). For each experiment, measurements were made of RV and LV regional segment lengths and pressures, along with proximal aortic and pulmonary arterial (PA) blood flow and pressure during the administration of 0, 0.5, 1.0, and 1.5 minimum alveolar anesthetic concentration (MAC) isoflurane. Contractility was assessed by calculating the regional preload recruitable stroke work slope (PRSW). Afterload was characterized in both nonpulsatile and pulsatile terms by calculating aortic input impedance magnitude (Z). From these data, total arterial resistance (R), characteristic impedance (Z(C)), and vascular compliance (C) were determined with reference to a three-element Windkessel model of the circulation. Additionally, steady- state (W(SS)), oscillatory (W(OS)), and total (W(T)) hydraulic power output of each ventricle was calculated. In the ISO group, isoflurane produced a nearly threefold greater decrease of peak systolic pressure in the LV than in the RV, yet the dose-related decrease of regional PRSW was virtually the same in both chambers. In the aorta, isoflurane produced a maximal 25% reduction in R at 1.0 MAC and doubled C without a significant change in Z(C). Alternatively, PAR was increased from baseline at 1.0 and 1.5 MAC, whereas Z(C) was increased from all other values at 1.5 MAC. PA C was not altered by isoflurane. In ISO+AB pigs, PA Z(C) at baseline was higher than that evident in ISO animals but was not altered by isoflurane. In contrast, baseline aortic R was lower in ISO+AB pigs but was still modestly reduced by 1.0 MAC isoflurane. In ISO animals, W(T) and W(SS) from both ventricles demonstrated dose-related decreases, but the reductions in LV W(T) and W(SS) were greater than those for the RV at all doses. Accordingly, the power requirement per unit flow decreased for the LV but remained constant for the RV. W(OS) for both ventricles was also reduced by isoflurane. However, the LV W(OS) to W(T) ratio increased, which indicates that more power was lost to the system by pulsation. In contrast, reductions in RV W(T) and W(OS) were nearly parallel at all isoflurane doses, and the W(OS) to W(T) ratio was unchanged. In the ISO+AB group, isoflurane-induced alterations in LV and RV power characteristics were similar to those in the ISO group. These data indicate that, despite similar effects on biventricular contractility, isoflurane exerts qualitatively different effects on RV and LV afterload, in part via alteration in autonomic nervous activity, that influence the distribution of power output between steady-state and pulsatile components. Implications: In this study, we examined the effects of isoflurane on cardiac performance in swine and found that, although the drug depresses contraction of both the left and right ventricles similarly, it has different effects on forces that oppose the ejection of blood. These findings demonstrate that the two interdependent pumps that comprise the heart can be influenced differently by anesthetic drugs.
Keywords: controlled study; dose response; nonhuman; animals; animal experiment; dose-response relationship, drug; blood pressure; heart; heart stroke volume; hemodynamics; swine; atropine; intravenous drug administration; ventricular function, left; nerve block; heart right ventricle; ventricular function, right; pulmonary artery; isoflurane; autonomic nervous system; hexamethonium; heart left ventricle; propranolol; aorta flow; lung artery pressure; anesthetics, general; hemodynamic processes; myocardial contraction; priority journal; article; inhalational drug administration; aorta pressure; artery resistance; blood vessel compliance; heart afterload; heart preload; heart ventricle contractility; depression, chemical
Journal Title: Anesthesia and Analgesia
Volume: 87
Issue: 3
ISSN: 0003-2999
Publisher: Lippincott Williams & Wilkins  
Date Published: 1998-09-01
Start Page: 511
End Page: 521
Language: English
PUBMED: 9728819
PROVIDER: scopus
DOI: 10.1213/00000539-199809000-00002
DOI/URL:
Notes: Article -- Export Date: 12 December 2016 -- Source: Scopus
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  1. Paul Heerdt
    45 Heerdt