Uterine tumors resembling ovarian sex-cord tumors have an immunophenotype consistent with true sex-cord differentiation Journal Article
| Authors: | Krishnamurthy, S.; Jungbluth, A. A.; Busam, K. J.; Rosai, J. |
| Article Title: | Uterine tumors resembling ovarian sex-cord tumors have an immunophenotype consistent with true sex-cord differentiation |
| Abstract: | Seven examples of Clement and Scully's type II uterine tumors resembling ovarian sex cord tumors were studied immunohistochemically with markers of sex cord, steroid cell differentiation (inhibin, O13, A103), or both, and were found to be immunoreactive for one or more of these markers in all cases. There was also constant immunoreactivity for vimentin and for hormone receptors and variable positivity for keratin, actin, and desmin. These findings provide strong evidence for the presence of true sex cord elements in these tumors, the derivation of which remains speculative. |
| Keywords: | immunohistochemistry; adult; clinical article; controlled study; human tissue; aged; middle aged; histopathology; actin; neoplasm proteins; steroid; ovary tumor; immunophenotyping; estrogen receptor; progesterone receptor; keratins; actins; uterine neoplasms; uterus; tissue differentiation; desmin; vimentin; sex cord tumor; uterus tumor; sex cord-gonadal stromal tumors; inhibin; endometrial stromal sarcoma; keratin; humans; human; female; article; ovarian sex cord tumors; steroid release |
| Journal Title: | American Journal of Surgical Pathology |
| Volume: | 22 |
| Issue: | 9 |
| ISSN: | 0147-5185 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 1998-09-01 |
| Start Page: | 1078 |
| End Page: | 1082 |
| Language: | English |
| DOI: | 10.1097/00000478-199809000-00006 |
| PUBMED: | 9737240 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 12 December 2016 -- Source: Scopus |
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