CD5 labeling of thymic carcinomas and other nonlymphoid neoplasms Journal Article
| Authors: | Kornstein, M. J.; Rosai, J. |
| Article Title: | CD5 labeling of thymic carcinomas and other nonlymphoid neoplasms |
| Abstract: | We studied 109 thymic tumors and 423 other neoplasms for immunocytochemical expression of CD5 in paraffin-embedded tissue using 2 monoclonal antibodies. One of the antibodies (clone CD5/54/B4) labeled 7 (29%) of 24 thymic carcinomas but did not-stain any of the other neoplasms. In contrast, the other antibody (clone 4C7) labeled 15 (62%) of 24 thymic carcinomas, 2 (2%) of 84 thymomas, 3 (8%) of 37 lymphomas, and 14 (4%) of 386 other tumors. Among the lymphomas, 4C7 labeled 2 of 4 peripheral T-cell lymphomas and 1 of 4 anaplastic large cell lymphomas. Clone 4C7 produced strong labeling of reactive T lymphocytes, whereas CD5/54/B4 staining of these cells was weak or absent. No other normal cells seemed to stain with either antibody. In conclusion, one CD5 antibody clone (CD5/54/B4) specifically identified 30% of thymic carcinomas. The other CD5 antibody (clone 4C7) identified 62% of thymic carcinomas but also labeled occasional other neoplasms. |
| Keywords: | immunohistochemistry; human tissue; unclassified drug; major clinical study; monoclonal antibody; immunoenzyme techniques; t cell lymphoma; antibodies, monoclonal; diagnostic value; immunocytochemistry; cell membrane; lymphoma; epithelial cells; cytoplasm; large cell lymphoma; thymoma; cd5 antigen; thymic carcinoma; thymus neoplasms; thymus cancer; paraffin; antigens, cd5; thymus lymphoma; humans; human; priority journal; article; tissue embedding; cd5; monoclonal antibody cd5 |
| Journal Title: | American Journal of Clinical Pathology |
| Volume: | 109 |
| Issue: | 6 |
| ISSN: | 0002-9173 |
| Publisher: | Oxford University Press |
| Date Published: | 1998-06-01 |
| Start Page: | 722 |
| End Page: | 726 |
| Language: | English |
| PUBMED: | 9620029 |
| PROVIDER: | scopus |
| DOI: | 10.1093/ajcp/109.6.722 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 12 December 2016 -- Source: Scopus |
