Patients with high-risk differentiated thyroid cancer have a lower I-131 ablation success rate than low-risk ones in spite of a high ablation activity Journal Article


Authors: Winter, J.; Winter, M.; Krohn, T.; Heinzel, A.; Behrendt, F. F.; Tuttle, R. M.; Mottaghy, F. M.; Verburg, F. A.
Article Title: Patients with high-risk differentiated thyroid cancer have a lower I-131 ablation success rate than low-risk ones in spite of a high ablation activity
Abstract: Objective: To examine success rates in strictly defined high-risk differentiated thyroid cancer (DTC) patients who received a high-activity (≥5550 MBq) adjuvant postoperative I-131 therapy and compare these to the rates found in highest risk and low-risk patients. Design: Retrospective database study. Patients: We examined 377 patients with DTC who received I-131 ablation. Patients with distant metastases were classified as very high risk. Patients with primary tumours >4 cm, extensive extrathyroidal invasion (pT4a or pT4b in accordance with the 7th edition of the TNM system), and patients with ≥5 lymph node metastases or any lateral compartment lymph node metastases were considered high risk. All other patients were considered low risk. Measurements: Ablation success rate at first TSH-stimulated follow-up. Results: The ablation success rate was 72·6% in low-risk patients, 51·7% in high-risk patients and 13·8% in highest risk patients (all differences P < 0·001). In none of the groups, a significant difference in the initial I-131 activity was found between patients with successful and unsuccessful ablation (low risk: P = 0·16, high risk: P = 0·91 and highest risk: P = 0·48). Furthermore, there was no difference in ablation success between patients who received <5550 MBq and those who received ≥5550 Mbq (low risk: P = 0·31, high risk: P = 0·69 and highest risk: P = 0·22). Conclusions: Patients with high-risk DTC have a significantly reduced I-131 ablation success rate compared to low-risk ones in spite of high initial I-131 activities. As successful ablation is prognostically important, efforts should be made to improve outcome in these patients. © 2016 John Wiley & Sons Ltd
Journal Title: Clinical Endocrinology
Volume: 85
Issue: 6
ISSN: 0300-0664
Publisher: Wiley Blackwell  
Date Published: 2016-12-01
Start Page: 926
End Page: 931
Language: English
DOI: 10.1111/cen.13123
PROVIDER: scopus
PUBMED: 27256714
DOI/URL:
Notes: Article -- Export Date: 6 December 2016 -- Source: Scopus
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  1. Robert M Tuttle
    350 Tuttle