Malignant peripheral nerve sheath tumor Journal Article
| Authors: | James, A. W.; Shurell, E.; Singh, A.; Dry, S. M.; Eilber, F. C. |
| Article Title: | Malignant peripheral nerve sheath tumor |
| Abstract: | Malignant peripheral nerve sheath tumor (MPNST) is the sixth most common type of soft tissue sarcoma. Most MPNSTs arise in association with a peripheral nerve or preexisting neurofibroma. Neurofibromatosis type is the most important risk factor for MPNST. Tumor size and fludeoxyglucose F 18 avidity are among the most helpful parameters to distinguish MPNST from a benign peripheral nerve sheath tumor. The histopathologic diagnosis is predominantly a diagnosis of light microscopy. Immunohistochemical stains are most helpful to distinguish high-grade MPNST from its histologic mimics. Current surgical management of high-grade MPNST is similar to that of other high-grade soft tissue sarcomas. © 2016 Elsevier Inc. |
| Keywords: | neurofibromatosis; malignant peripheral nerve sheath tumor; neurofibroma; nf1; atypical neurofibroma |
| Journal Title: | Surgical Oncology Clinics of North America |
| Volume: | 25 |
| Issue: | 4 |
| ISSN: | 1055-3207 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2016-10-01 |
| Start Page: | 789 |
| End Page: | 802 |
| Language: | English |
| DOI: | 10.1016/j.soc.2016.05.009 |
| PROVIDER: | scopus |
| PUBMED: | 27591499 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 6 December 2016 -- Source: Scopus |
