Hip-related toxicity after prostate radiotherapy: Treatment related or coincidental? Journal Article
| Authors: | Zelefsky, M. J.; Kollmeier, M. A.; Gorshein, E.; Pei, X.; Torres, M.; McBride, S.; Happersett, L.; Cohen, G. N.; Yamada, Y. |
| Article Title: | Hip-related toxicity after prostate radiotherapy: Treatment related or coincidental? |
| Abstract: | Background and purpose To evaluate the incidence and predictors of hip toxicity postradiotherapy for localized prostate cancer. Methods and materials 4067 prostate cancer patients were treated with external beam radiotherapy (EBRT; n = 2569; 63%) or brachytherapy with or without supplemental EBRT (n = 1508; 27%). 43% (n = 1738) were treated with neo-adjuvant and concurrent ADT and 57% (n = 2329) with radiotherapy alone. Hip toxicity was defined as moderate or severe pain upon ambulation with or without the need for hip-revision surgery. Median follow-up was 7 years (range, 3–21 years). Results One hundred twenty-one (2.7%) patients developed moderate-to-severe hip pain after radiotherapy affecting ambulation. Of these, 73 (60%) required hip replacement secondary to persistent hip pain. Among patients with baseline degenerative joint disease (DJD) changes on scans, 10-year incidence of hip-related toxicity was 11% versus 3% for those without such changes (P < .001). The only variables on multivariate analysis associated with hip-related toxicity post-radiotherapy were baseline DJD on imaging (P < .0001) and prolonged ADT for salvage therapy (P < .0001). Conclusions Prostate EBRT or brachytherapy is associated with low incidence of long-term hip-related toxicity. The only variables identified associated with hip toxicity posttherapy was the presence of baseline DJD and prolonged salvage ADT posttreatment for patients developing recurrence. © 2016 Elsevier Ireland Ltd |
| Keywords: | prostate cancer; brachytherapy; external beam radiotherapy; toxicity; hip replacement |
| Journal Title: | Radiotherapy and Oncology |
| Volume: | 121 |
| Issue: | 1 |
| ISSN: | 0167-8140 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2016-10-01 |
| Start Page: | 109 |
| End Page: | 112 |
| Language: | English |
| DOI: | 10.1016/j.radonc.2016.08.010 |
| PROVIDER: | scopus |
| PUBMED: | 27756494 |
| PMCID: | PMC5546832 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 6 December 2016 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
Related MSK Work