Cytoreductive surgery and intraperitoneal chemotherapy: An evidence-based review-past, present and future Journal Article
| Authors: | Dehal, A.; Smith, J. J.; Nash, G. M. |
| Article Title: | Cytoreductive surgery and intraperitoneal chemotherapy: An evidence-based review-past, present and future |
| Abstract: | Peritoneal carcinomatosis (PC) has historically been considered a terminal condition with merely palliative treatment achieving a survival rate measured in months. Cytoreductive surgery (CyRS) and intraperitoneal chemotherapy (IPC) have emerged as potentially effective regional treatments with the potential for long-term survival in well-selected patients. The fundamentals of CyRS and IPC are patient selection and complete cytoreduction. Since there is now sufficient evidence for the superiority of CyRS and IPC to systemic chemotherapy alone in a highly select group of patients, surgeons and oncologists should be aware of this modality as a potential benefit for patients with PC. The aim of this report is to highlight cancer-specific evidence in the context of ongoing studies regarding the outcome of this treatment. © Journal of Gastrointestinal Oncology. |
| Keywords: | cancer chemotherapy; cancer survival; treatment response; overall survival; review; cisplatin; doxorubicin; fluorouracil; drug efficacy; patient selection; treatment duration; paclitaxel; disease free survival; cancer staging; lymph node metastasis; antineoplastic agent; cancer grading; colorectal cancer; cytoreductive surgery; carboplatin; progression free survival; ovary cancer; peritoneum cancer; evidence based practice; cancer research; histology; postoperative complication; cause of death; folinic acid; mesothelioma; stomach cancer; carcinomatous peritonitis; uterine tube carcinoma; mitomycin; peritoneum metastasis; disease specific survival; peritoneum mesothelioma; gastric cancer; recurrence free survival; peritoneum pseudomyxoma; appendix cancer; peritoneal mesothelioma; randomized controlled trial (topic); phase 2 clinical trial (topic); phase 3 clinical trial (topic); phase 1 clinical trial (topic); multicenter study (topic); cancer prognosis; long term survival; hyperthermic intraperitoneal chemotherapy; human; early postoperative intraperitoneal chemotherapy (epic); hyperthermic intraperitoneal chemotherapy (hipec); appendiceal mucinous neoplasms; colorectal cancer (crc); cytoreductive surgery (cyrs); intraperitoneal chemotherapy (ipc); peritoneal carcinomatosis (pc); early postoperative intraperitoneal chemotherapy; ovarian cancer and mixed types of peritoneal cancer (oc and mixed types of peritoneal cancer) |
| Journal Title: | Journal of Gastrointestinal Oncology |
| Volume: | 7 |
| Issue: | 1 |
| ISSN: | 2078-6891 |
| Publisher: | Pioneer Bioscience Publishing Company |
| Date Published: | 2016-02-01 |
| Start Page: | 143 |
| End Page: | 157 |
| Language: | English |
| DOI: | 10.3978/j.issn.2078-6891.2015.112 |
| PROVIDER: | scopus |
| PMCID: | PMC4754310 |
| PUBMED: | 26941992 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 6 December 2016 -- Source: Scopus |
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