Encouraging experience in the treatment of nasal type extra-nodal NK/T-cell lymphoma in a non-Asian population Journal Article
| Authors: | Qi, S.; Yahalom, J.; Hsu, M.; Chelius, M.; Lunning, M.; Moskowitz, A.; Horwitz, S. |
| Article Title: | Encouraging experience in the treatment of nasal type extra-nodal NK/T-cell lymphoma in a non-Asian population |
| Abstract: | Extra-nodal NK/T-cell lymphoma, nasal type (EN-NK/TCL-NT), is rare in the Western world. We launched the current single-institutional retrospective study with Institutional Review Board approval to better understand the disease. 43 EN-NK/TCL-NT patients treated from 1996 to 2014 were analyzed, including 10 (23%) Asians and 33 (76%) non-Asians. 19/26 (73%) early-stage patients received short-course chemotherapy followed by radiotherapy. 14/17 (82%) advanced-stage patients received primary chemotherapy. Complete response rate was significantly higher in the modified-SMILE group than the accelerated-CHOP group (80% vs. 30%, p = 0.015). The 2-year overall survival (OS) and progression-free survival (PFS) were 60% and 40%, respectively. Early-stage disease had significantly higher 2-year OS (87% vs. 21%) and PFS (56% vs.18%) than advanced-stage (p < 0.001). Ethnicity had no prognostic difference. EN-NK/TCL-NT in non-Asians shared similar disease characteristics and treatment outcomes with Asians. Most early-stage patients have achieved durable remissions. Management of advanced-stage disease remains challenging, with frequent progression and high mortality. © 2016 Informa UK Limited, trading as Taylor & Francis Group. |
| Keywords: | radiotherapy; drug therapy; ethnology; smile; extranodal nk-t-cell lymphomas |
| Journal Title: | Leukemia and Lymphoma |
| Volume: | 57 |
| Issue: | 11 |
| ISSN: | 1042-8194 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2016-05-17 |
| Start Page: | 2575 |
| End Page: | 2583 |
| Language: | English |
| DOI: | 10.1080/10428194.2016.1180689 |
| PROVIDER: | scopus |
| PUBMED: | 27183991 |
| PMCID: | PMC5592793 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 November 2016 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work