Expression levels of DNA damage repair proteins are associated with overall survival in platinum-treated advanced urothelial carcinoma Journal Article
| Authors: | Mullane, S. A.; Werner, L.; Guancial, E. A.; Lis, R. T.; Stack, E. C.; Loda, M.; Kantoff, P. W.; Choueiri, T. K.; Rosenberg, J.; Bellmunt, J. |
| Article Title: | Expression levels of DNA damage repair proteins are associated with overall survival in platinum-treated advanced urothelial carcinoma |
| Abstract: | Micro-Abstract In a cohort of 104 patients with metastatic urothelial carcinoma (mUC) who had received platinum therapy, we examined the correlation between ERCC1, RAD51, PARP-1, PAR, BRCA1, and BRCA2 and overall survival (OS). A greater percentage of nuclear staining of ERCC1 (hazard ratio [HR], 2.7; 95% confidence interval [CI], 1.5-4.9; P =.0007), RAD51 (HR, 5.6; 95% CI, 1.7-18.3; P =.005), and PAR (HR, 2.2; 95% CI, 1.1-4.4; P =.026) was associated with worse OS. © 2015 Elsevier Inc. |
| Keywords: | immunohistochemistry; dna damage; bladder cancer; platinum chemotherapy |
| Journal Title: | Clinical Genitourinary Cancer |
| Volume: | 14 |
| Issue: | 4 |
| ISSN: | 1558-7673 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2016-08-01 |
| Start Page: | 352 |
| End Page: | 359 |
| Language: | English |
| DOI: | 10.1016/j.clgc.2015.12.029 |
| PROVIDER: | scopus |
| PUBMED: | 26778300 |
| PMCID: | PMC5508512 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 November 2016 -- Source: Scopus |
