Biomarkers that predict sensitivity to heat shock protein 90 inhibitors Journal Article
| Authors: | Jhaveri, K.; Chandarlapaty, S.; Iyengar, N.; Morris, P. G.; Corben, A. D.; Patil, S.; Akram, M.; Towers, R.; Sakr, R. A.; King, T. A.; Norton, L.; Rosen, N.; Hudis, C.; Modi, S. |
| Article Title: | Biomarkers that predict sensitivity to heat shock protein 90 inhibitors |
| Abstract: | Micro-Abstract There is a lack of predictive biomarkers that can help determine a subset of patients who might most benefit from treatment with heat shock protein 90 (HSP90) inhibitors. Results from this retrospective tissue analysis from advanced solid tumor patients (most with breast cancer) who were treated with various HSP90 inhibitors suggest that HER2 might be the only effective biomarker of sensitivity to HSP90 inhibitors. © 2015 Elsevier Inc. |
| Keywords: | biomarker; solid tumors; her2; hsp90; client proteins |
| Journal Title: | Clinical Breast Cancer |
| Volume: | 16 |
| Issue: | 4 |
| ISSN: | 1526-8209 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2016-08-01 |
| Start Page: | 276 |
| End Page: | 283 |
| Language: | English |
| DOI: | 10.1016/j.clbc.2015.11.004 |
| PROVIDER: | scopus |
| PUBMED: | 26726007 |
| PMCID: | PMC5242238 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 November 2016 -- Source: Scopus |
