Estimating the harms and benefits of prostate cancer screening as used in common practice versus recommended good practice: A microsimulation screening analysis Journal Article


Authors: Carlsson, S. V.; de Carvalho, T. M.; Roobol, M. J.; Hugosson, J.; Auvinen, A.; Kwiatkowski, M.; Villers, A.; Zappa, M.; Nelen, V.; Páez, A.; Eastham, J. A.; Lilja, H.; de Koning, H. J.; Vickers, A. J.; Heijnsdijk, E. A. M.
Article Title: Estimating the harms and benefits of prostate cancer screening as used in common practice versus recommended good practice: A microsimulation screening analysis
Abstract: BACKGROUND: Prostate-specific antigen (PSA) screening and concomitant treatment can be implemented in several ways. The authors investigated how the net benefit of PSA screening varies between common practice versus “good practice.”. METHODS: Microsimulation screening analysis (MISCAN) was used to evaluate the effect on quality-adjusted life-years (QALYs) if 4 recommendations were followed: limited screening in older men, selective biopsy in men with elevated PSA, active surveillance for low-risk tumors, and treatment preferentially delivered at high-volume centers. Outcomes were compared with a base model in which annual screening started at ages 55 to 69 years and were simulated using data from the European Randomized Study of Screening for Prostate Cancer. RESULTS: In terms of QALYs gained compared with no screening, for 1000 screened men who were followed over their lifetime, recommended good practice led to 73 life-years (LYs) and 74 QALYs gained compared with 73 LYs and 56 QALYs for the base model. In contrast, common practice led to 78 LYs gained but only 19 QALYs gained, for a greater than 75% relative reduction in QALYs gained from unadjusted LYs gained. The poor outcomes for common practice were influenced predominantly by the use of aggressive treatment for men with low-risk disease, and PSA testing in older men also strongly reduced potential QALY gains. CONCLUSIONS: Commonly used PSA screening and treatment practices are associated with little net benefit. Following a few straightforward clinical recommendations, particularly greater use of active surveillance for low-risk disease and reducing screening in older men, would lead to an almost 4-fold increase in the net benefit of prostate cancer screening. Cancer 2016;122:3386–3393. © 2016 American Cancer Society. © 2016 American Cancer Society
Keywords: quality of life; mass screening; prostatic neoplasms; prostate-specific antigen/blood; early detection of cancer/adverse effects; quality-adjusted-life-years
Journal Title: Cancer
Volume: 122
Issue: 21
ISSN: 0008-543X
Publisher: Wiley Blackwell  
Date Published: 2016-11-01
Start Page: 3386
End Page: 3393
Language: English
DOI: 10.1002/cncr.30192
PROVIDER: scopus
PMCID: PMC5073010
PUBMED: 27459245
DOI/URL:
Notes: Article -- Export Date: 1 November 2016 -- Source: Scopus
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MSK Authors
  1. Hans Gosta Lilja
    286 Lilja
  2. Andrew J Vickers
    556 Vickers
  3. James Eastham
    426 Eastham