Exercise and prognosis on the basis of clinicopathologic and molecular features in early-stage breast cancer: The LACE and pathways studies Journal Article

   

Authors:	Jones, L. W.; Kwan, M. L.; Weltzien, E.; Chandarlapaty, S.; Sternfeld, B.; Sweeney, C.; Bernard, P. S.; Castillo, A.; Habel, L. A.; Kroenke, C. H.; Langholz, B. M.; Queensberry, C. P. Jr; Dang, C.; Weigelt, B.; Kushi, L. H.; Caan, B. J.
Article Title:	Exercise and prognosis on the basis of clinicopathologic and molecular features in early-stage breast cancer: The LACE and pathways studies
Abstract:	To investigate whether the impact of postdiagnosis exercise on breast cancer outcomes in women diagnosed with early-stage breast cancer differs on the basis of tumor clinicopathologic and molecular features. Using a prospective design, 6,211 patients with early-stage breast cancer from two large population-based cohort studies were studied. Age-adjusted and multivariable Cox regression models were performed to determine the relationship between exercise exposure (total MET-hours/week) and recurrence and breast cancer-related death for: (i) all patients ("unselected" cohort), and on the basis of (ii) classic clinicopathologic features, (iii) clinical subtypes, (iv) PAM50-based molecular intrinsic subtypes, and (v) individual PAM50 target genes. After a median follow-up of 7.2 years, in the unselected cohort (n = 6,211) increasing exercise exposure was not associated with a reduction in the risk of recurrence (adjusted Ptrend = 0.60) or breast cancer-related death (adjusted Ptrend = 0.39). On the basis of clinicopathologic features, an exercise-associated reduction in breast cancer-related death was apparent for tumors <2 cm [HR, 0.50; 95% confidence interval (CI), 0.34-0.72], well/moderately differentiated tumors (HR, 0.63; 95% CI, 0.43-0.91), and ER-positive tumors (HR, 0.72; 95% CI, 0.53-0.97). Stratification by clinical subtype indicated that the ER+/PR+/HER2-/low-grade clinical subtype was preferentially responsive to exercise (recurrence: adjusted HR, 0.63; 95% CI, 0.45-0.88; breast cancer-related death: adjusted HR, 0.57; 95% CI, 0.37-0.86). The impact of exercise on cancer outcomes appears to differ as a function of pathologic and molecular features in early-stage breast cancer. ©2016 AACR.
Journal Title:	Cancer Research
Volume:	76
Issue:	18
ISSN:	0008-5472
Publisher:	American Association for Cancer Research
Date Published:	2016-09-15
Start Page:	5415
End Page:	5422
Language:	English
DOI:	10.1158/0008-5472.can-15-3307
PROVIDER:	scopus
PMCID:	PMC5026589
PUBMED:	27488523
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84988939436&partnerID=40&md5=241a7898fc15cfc747fe92f16eacf0c2
Notes:	Article -- Export Date: 2 November 2016 -- Source: Scopus

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