Synapse - Andrea Basso

Results (32)

Ansamycins inactivate AKT and enhances the anti-tumor effects of paclitaxel

Meeting Abstract

Solit, D.; Basso, A.; Munster, P.; Scher, H.; Rosen, N.
European Journal of Cancer (2002)

Degradation of HER2 by ansamycins induces growth arrest and apoptosis in cells with HER2 overexpression via a HER3, phosphatidylinositol 3 '-kinase-AKT-dependent pathway

Journal Article

Munster, P. N.; Marchion, D. C.; Basso, A. D.; Rosen, N.
Cancer Research (2002)

Fulltext@MSK | Save

Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2

Journal Article

Basso, A. D.; Solit, D. B.; Munster, P. N.; Rosen, N.
Oncogene (2002)

Fulltext@MSK | Save

Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function

Journal Article

Basso, A. D.; Solit, D. B.; Chiosis, G.; Giri, B.; Tsichlis, P.; Rosen, N.
Journal of Biological Chemistry (2002)

Fulltext@MSK | Save

Modulation of Hsp90 function by ansamycins enhances chemotherapy induced apoptosis in breast cancer cell lines in an RB and schedule dependent manner

Meeting Abstract

Munster, P. N.; Basso, A. D.; Solit, D.; Norton, L.; Scher, H.; Rosen, N.
Proceedings of the American Association for Cancer Research Annual Meeting (2001)

Fulltext@MSK | Save

Ansamycins inhibit Akt activation and induce the 20S proteasomal degradation of Akt protein

Meeting Abstract

Basso, A. D.; Solit, D. B.; Rosen, N.
Clinical Cancer Research (2001)

Fulltext@MSK | Save

The tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumors

Meeting Abstract

Moasser, M. M.; Basso, A. D.; Averbuch, S. D.; Rosen, N.
Clinical Cancer Research (2001)

Fulltext@MSK | Save

17-Allylamino-geldanamycin causes AKT inactivation and enhances the anti-tumor effects of paclitaxel

Meeting Abstract

Solit, D. B.; Basso, A. D.; Munster, P. N.; Norton, L.; Scher, H. I.; Rosen, N.
Clinical Cancer Research (2001)

Fulltext@MSK | Save

Modulation of Hsp90 function by ansamycins sensitizes breast cancer cells to chemotherapy-induced apoptosis in an RB- and schedule-dependent manner. See: The Biology Behind: E. A. Sausville, Combining cytotoxics and 17-allylamino, 17-demethoxygeldanamycin: Sequence and tumor biology matters. Clin. Cancer Res., 7: 2155-2158, 2001