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Andrea D. Basso

  1. "Human Oncology and Pathogenesis Program"
Formats
  1. Meeting Abstract (16)
  2. Journal Article (9)
Groups
  1. Department of Medicine (25)
  2. GSK Faculty (25)
  3. Genitourinary Oncology Service (25)
  4. Human Oncology and Pathogenesis Program (25)
  5. Solid Tumor Oncology Division (25)
  6. Breast Medicine Service (24)

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People
  1. David Solit (25)
  2. Neal Rosen (24)
  3. Pamela Munster (7)
  4. Howard Scher (6)
  5. Olivera Grbovic-Huezo (6)
  6. Ayana Sawai (5)

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Years
  1. 2006 (2)
  2. 2005 (3)
  3. 2004 (3)
  4. 2003 (6)
  5. 2002 (5)
  6. 2001 (4)

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Publications
  1. Clinical Cancer Research (8)
  2. Cancer Research (5)
  3. Proceedings of the American Association for Cancer Research Annual Meeting (4)
  4. Breast Cancer Research and Treatment (1)
  5. Chemistry and Biology (1)
  6. Current Cancer Drug Targets (1)

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Publishers
  1. American Association for Cancer Research (17)
  2. Elsevier Inc. (2)
  3. Nature Publishing Group (2)
  4. American Society for Biochemistry and Molecular Biology (1)
  5. Bentham Science Publishers (1)
  6. National Academy of Sciences (1)

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Results (25)

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  • Activated, mutated B-Raf protein kinase requires the Hsp90 chaperone protein for folding and stability and is degraded in response to Hsp90 inhibitors
    Meeting Abstract

    Grbovic, O. M.; Basso, A. D.; Houghton, A.; Solit, D. B.; Rosen, N.
    Clinical Cancer Research (2003)

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  • Development of purine-scaffold small molecule inhibitors of Hsp90
    Journal Article

    Chiosis, G.; Lucas, B.; Huezo, H.; Solit, D.; Basso, A.; Rosen, N.
    Current Cancer Drug Targets (2003)

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  • Inhibition of heat shock protein 90 function down-regulates Akt kinase and sensitizes tumors to Taxol
    Journal Article

    Solit, D. B.; Basso, A. D.; Olshen, A. B.; Scher, H. I.; Rosen, N.
    Cancer Research (2003)

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  • Resistance to gefitinib in PTEN-Null HER-overexpressing tumor cells can be overcome through restoration of PTEN function or pharmacologic modulation of constitutive phosphatidylinositol 3′-kinase/Akt pathway signaling
    Journal Article

    She, Q. B.; Solit, D.; Basso, A.; Moasser, M. M.
    Clinical Cancer Research (2003)

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  • Identification and synthesis of novel small molecules that bind to and modulate Hsp90 function
    Meeting Abstract

    Solit, D. B.; Basso, A.; Huezo, H.; Shtil, A.; Rosen, N.; Chiosis, G.
    Proceedings of the American Association for Cancer Research Annual Meeting (2002)

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  • The Akt protein kinase is a direct target of ansamycin antibiotics
    Meeting Abstract

    Basso, A. D.; Solit, D.; Rosen, N.
    Proceedings of the American Association for Cancer Research Annual Meeting (2002)

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  • Ansamycins inactivate AKT and enhances the anti-tumor effects of paclitaxel
    Meeting Abstract

    Solit, D.; Basso, A.; Munster, P.; Scher, H.; Rosen, N.
    European Journal of Cancer (2002)

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  • Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2
    Journal Article

    Basso, A. D.; Solit, D. B.; Munster, P. N.; Rosen, N.
    Oncogene (2002)

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  • Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function
    Journal Article

    Basso, A. D.; Solit, D. B.; Chiosis, G.; Giri, B.; Tsichlis, P.; Rosen, N.
    Journal of Biological Chemistry (2002)

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  • Modulation of Hsp90 function by ansamycins enhances chemotherapy induced apoptosis in breast cancer cell lines in an RB and schedule dependent manner
    Meeting Abstract

    Munster, P. N.; Basso, A. D.; Solit, D.; Norton, L.; Scher, H.; Rosen, N.
    Proceedings of the American Association for Cancer Research Annual Meeting (2001)

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