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William Douglas Tap

  1. "Human Oncology and Pathogenesis Program"
Formats
  1. Journal Article (55)
  2. Meeting Abstract (44)
  3. Research Letter (1)
  4. Review (1)
Groups
  1. Department of Medicine (101)
  2. GSK Faculty (101)
  3. Human Oncology and Pathogenesis Program (101)
  4. Sarcoma Service (101)
  5. Solid Tumor Oncology Division (101)
  6. Tow Center for Developmental Oncology (TCDO) (95)

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People
  1. Ping Chi (69)
  2. Sandra D'Angelo (58)
  3. Mrinal Gounder (57)
  4. Mary Keohan (56)
  5. Mark Dickson (54)
  6. Cristina Antonescu (53)

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Years
  1. 2025 (3)
  2. 2024 (12)
  3. 2023 (14)
  4. 2022 (17)
  5. 2021 (5)
  6. 2020 (11)

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Publications
  1. Journal of Clinical Oncology (31)
  2. Clinical Cancer Research (12)
  3. Annals of Oncology (6)
  4. Modern Pathology (4)
  5. Annals of Surgical Oncology (3)
  6. Cancer Research (3)

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Publishers
  1. American Society of Clinical Oncology (34)
  2. American Association for Cancer Research (19)
  3. Nature Publishing Group (9)
  4. Oxford University Press (8)
  5. Springer (6)
  6. Nature Research (4)

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Results (101)

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  • Targeted sequencing of 2,138 bone and soft tissue sarcomas reveals commonly altered pathways, subtype-independent genetic clusters, and potential therapeutic targets
    Meeting Abstract

    Nacev, B. A.; Sanchez-Vega, F.; Smith, S.; Antonescu, C.; Rosenbaum, E.; Shi, H.; Tang, C.; Socci, N.; Rana, S.; Gularte-Merida, R.; more...
    Clinical Cancer Research (2022)

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  • Distinct IDH1/2-associated methylation profile and enrichment of TP53 and TERT mutations distinguish dedifferentiated chondrosarcoma from conventional chondrosarcoma on integrated genomic and epigenomic profiling
    Meeting Abstract

    Dermawan, J.; Nafa, K.; Mohanty, A.; Xu, Y.; Rijo, I.; Villafania, L.; Benhamida, J.; Kelly, C.; Tap, W.; Boland, P.; more...
    Journal of Molecular Diagnostics (2022)

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  • The genetic landscape of SMARCB1 alterations in SMARCB1-deficient spectrum of mesenchymal neoplasms
    Journal Article

    Dermawan, J. K.; Singer, S.; Tap, W. D.; Nacev, B. A.; Chi, P.; Wexler, L. H.; Ortiz, M. V.; Gounder, M.; Antonescu, C. R.
    Modern Pathology (2022)

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  • A phase I/II trial of the PD-1 inhibitor retifanlimab (R) in combination with gemcitabine and docetaxel (GD) as first-line therapy in patients (Pts) with advanced soft-tissue sarcoma (STS)
    Meeting Abstract

    Rosenbaum, E.; Qin, L. X.; Thornton, K. A.; Movva, S.; Nacev, B. A.; Dickson, M. A.; Gounder, M. M.; Keohan, M. L.; Avutu, V.; Chi, P.; more...
    Journal of Clinical Oncology (2022)

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  • Presence of immune infiltrates, increased expression of transposable elements, and viral response pathways in sarcoma associate with response to checkpoint inhibition
    Meeting Abstract

    Nacev, B. A.; Bradic, M.; Richards, A. L.; Kelly, C. M.; Dickson, M. A.; Gounder, M. M.; Keohan, M. L.; Chi, P.; Movva, S.; Thornton, K. A.; more...
    Journal of Clinical Oncology (2022)

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  • Subclonal somatic copy number alterations emerge and dominate in recurrent osteosarcoma
    Meeting Abstract

    Kinnaman, M. D.; Zaccaria, S.; Makohon-Moore, A.; Gundem, G.; Ossa, J. E. A.; Bouvier, N.; Dela Cruz, F. S.; Hameed, M.; Bender, J. L. G.; Tap, W. D.; more...
    Journal of Clinical Oncology (2022)

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  • Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets
    Journal Article

    Nacev, B. A.; Sanchez-Vega, F.; Smith, S. A.; Antonescu, C. R.; Rosenbaum, E.; Shi, H.; Tang, C.; Socci, N. D.; Rana, S.; Zehir, A.; more...
    Nature Communications (2022)

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  • Pilot study of bempegaldesleukin in combination with nivolumab in patients with metastatic sarcoma
    Journal Article

    D'Angelo, S. P.; Richards, A. L.; Conley, A. P.; Woo, H. J.; Dickson, M. A.; Gounder, M.; Kelly, C.; Keohan, M. L.; Movva, S.; Thornton, K.; more...
    Nature Communications (2022)

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  • Clinical genomic profiling in the management of patients with soft tissue and bone sarcoma
    Journal Article

    Gounder, M. M.; Agaram, N. P.; Trabucco, S. E.; Robinson, V.; Ferraro, R. A.; Millis, S. Z.; Krishnan, A.; Lee, J.; Attia, S.; Abida, W.; more...
    Nature Communications (2022)

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  • FGFR2::TACC2 fusion as a novel KIT-independent mechanism of targeted therapy failure in a multidrug-resistant gastrointestinal stromal tumor
    Journal Article

    Dermawan, J. K.; Vanderbilt, C. M.; Chang, J. C.; Untch, B. R.; Singer, S.; Chi, P.; Tap, W. D.; Antonescu, C. R.
    Genes Chromosomes and Cancer (2022)

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