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Francis M Sirotnak

Results (184)

Expression and differential polarization of the reduced-folate transporter-1 and the folate receptor alpha in mammalian retinal pigment epithelium

Journal Article

Chancy, C. D.; Kekuda, R.; Huang, W.; Prasad, P. D.; Kuhnel, J. M.; Sirotnak, F. M.; Roon, P.; Ganapathy, V.; Smith, S. B.
Journal of Biological Chemistry (2000)

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Two promoters regulate transcription of the mouse folylpolyglutamate synthetase gene: Three tightly clustered Sp1 sites within the first intron markedly enhance activity of promoter B

Journal Article

Chen, J.; Hayes, P.; Roy, K.; Sirotnak, F. M.
Gene (2000)

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Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase

Journal Article

Sirotnak, F. M.; Zakowski, M. F.; Miller, V. A.; Scher, H. I.; Kris, M. G.
Clinical Cancer Research (2000)

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Co-administration of probenecid, an inhibitor of a cMOAT/MRP-like plasma membrane ATPase, greatly enhanced the efficacy of a new 10-deazaaminopterin against human solid tumors in vivo

Journal Article

Sirotnak, F. M.; Wendel, H. G.; Bornmann, W. G. B.; Tong, W. P.; Miller, V. A.; Scher, H. I.; Kris, M. G.
Clinical Cancer Research (2000)

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Phase I and pharmacokinetic study of 10-propargyl-10-deazaaminopterin, a new antifolate

Journal Article

Krug, L. M.; Ng, K. K.; Kris, M. G.; Miller, V. A.; Tong, W.; Heelan, R. T.; Leon, L.; Leung, D.; Kelly, J.; Sirotnak, F. M.
Clinical Cancer Research (2000)

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A peptidomimetic inhibitor of ras functionality markedly suppresses growth of human prostate tumor xenografts in mice. Prospects for long-term clinical utility

Journal Article

Sirotnak, F. M.; Sepp-Lorenzino, L.; Kohl, N. E.; Rosen, N.; Scher, H. I.
Cancer Chemotherapy and Pharmacology (2000)

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Markedly decreased binding of vincristine to tubulin in vinca alkaloid-resistant Chinese hamster cells is associated with selective overexpression of alpha and beta tubulin isoforms

Journal Article

Sirotnak, F. M.; Danenberg, K. D.; Chen, J.; Fritz, F.; Danenberg, P. V.
Biochemical and Biophysical Research Communications (2000)

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Phase I and pharmacokinetic study of 10-propargyl-10-deazaaminopterin (PDX), a new antifolate

Meeting Abstract

Krug, L. M.; Ng, K. K.; Miller, V. A.; Heelan, R. T.; Tong, W.; Kelly, J.; Sirotnak, F. M.; Kris, M. G.
Clinical Cancer Research (1999)

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Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by co-administration of ZD1839 (Iressa™), an inhibitor of EGF receptor tyrosine kinase

Meeting Abstract

Sirotnak, F. M.; Miller, V. A.; Scher, H. I.; Kris, M. G.
Clinical Cancer Research (1999)

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Co-administration of probenecid, an inhibitor of a cMOAT/MRP-like plasma membrane ATPase, greatly enhanced the efficacy of a new 10-deazaaminopterin against human solid tumors in vivo

Meeting Abstract

Sirotnak, F. M.; Bornmann, W. G. B.; Miller, V. A.; Scher, H. I.; Kris, M. G.
Clinical Cancer Research (1999)

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