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Francis M Sirotnak

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Enhancement of folate analogue transport inward in L1210 cells during methotrexate therapy of leukemic mice: Evidence of the nature of the effect, possible host mediation, and pharmacologic significance

Journal Article

Sirotnak, F. M.; Poser, R. E.; Barrueco, J. R.
Cancer Research (1987)

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Toxicity, elimination, and metabolism of 10-ethyl-10-deazaaminopterin in rats and dogs

Journal Article

Fanucchi, M. P.; Kinahan, J. J.; Samuels, L. L.; Hancock, C.; Chou, T. C.; Niedzwiecki, D.; Farag, F.; Vidal, P. M.; DeGraw, J. I.; Sternberg, S. S.; more...
Cancer Research (1987)

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Proposed mechanism of therapeutic selectivity for 9-β-D-arabinofuranosyl-2-fluoroadenine against murine leukemia based upon lower capacities for transport and phosphorylation in proliferative intestinal epithelium compared to tumor cells

Journal Article

Barrueco, J. R.; Jacobsen, D. M.; Chang, C. H.; Brockman, R. W.; Sirotnak, F. M.
Cancer Research (1987)

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Membrane transport and the antineoplastic action of nucleoside analogues

Journal Article

Sirotnak, F. M.; Barrueco, J. R.
Cancer and Metastasis Reviews (1987)

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Carrier-mediated transport of folate compounds in L1210 cells: Initial rate kinetics and extent of duality of entry routes for folic acid and diastereomers of 5-methyltetrahydrohomofolate in the presence of physiological anions

Journal Article

Sirotnak, F. M.; Goutas, L. J.; Jacobsen, D. M.; Mines, L. S.; Barrueco, J. R.; Gaumont, Y.; Kisliuk, R. L.
Biochemical Pharmacology (1987)

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The 10-deaza-aminopterins: Rational design with increased therapeutic selectivity

Meeting Abstract

Sirotnak, F. M.
Abstracts of Papers of the American Chemical Society (1986)

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Inhibitory action of the 10-deazaaminopterins and their polyglutamates on human thymidylate synthetase

Meeting Abstract

Ueda, T.; Dutschman, G. E.; Nair, M. G.; DeGraw, J. I.; Sirotnak, F. M.; Chang, Y. C.
Proceedings of the American Association for Cancer Research Annual Meeting (1986)

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Higher levels of membrane transport and phosphorylation of 9-β-Arabinofuranosyl-2-fluoroadenine in L1210 cells than in proliferative epithelium from mouse small intestine therapeutic implications

Meeting Abstract

Barrueco, J. R.; Jacobsen, D. M.; Chang, C. H.; Brockman, R. W.; Sirotnak, F. M.
Proceedings of the American Association for Cancer Research Annual Meeting (1986)

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Inhibitory action of 10-deazaaminopterins and their polyglutamates on human thymidylate synthase

Journal Article

Ueda, T.; Dutschman, G. E.; Nair, M. G.; Degraw, J. I.; Sirotnak, F. M.; Cheng, Y. C.
Molecular Pharmacology (1986)

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Hydrolytic cleavage of methotrexate γ-polyglutamates by folylpolyglutamyl hydrolase derived from various tumors and normal tissues of the mouse

Journal Article

Samuels, L. L.; Goutas, L. J.; Priest, D. G.; Piper, J. R.; Sirotnak, F. M.
Cancer Research (1986)

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