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Manickam Janakiraman

  1. "Molecular Pharmacology and Chemistry Program Faculty"
Formats
  1. Meeting Abstract (9)
  2. Journal Article (3)
Groups
  1. Breast Medicine Service (12)
  2. Department of Medicine (12)
  3. GSK Faculty (12)
  4. Genitourinary Oncology Service (12)
  5. Human Oncology and Pathogenesis Program (12)
  6. Molecular Pharmacology and Chemistry Program Faculty (12)

More Groups

People
  1. David Solit (12)
  2. Neal Rosen (12)
  3. Yogindra Persaud (8)
  4. Christine Pratilas (6)
  5. Poulikos Poulikakos (5)
  6. Barry Taylor (4)

More People

Years
  1. 2012 (3)
  2. 2011 (2)
  3. 2010 (2)
  4. 2009 (3)
  5. 2008 (1)
  6. 2007 (1)
Publications
  1. Cancer Research (8)
  2. Cancer Discovery (1)
  3. European Journal of Cancer (1)
  4. Molecular Cancer Therapeutics (1)
  5. Nature (1)
Publishers
  1. American Association for Cancer Research (10)
  2. Elsevier Inc. (1)
  3. Nature Publishing Group (1)

Results (12)

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  • RAS-independent dimerization of BRAF(V600E) splicing variants promotes resistance to RAF inhibitors
    Meeting Abstract

    Poulikakos, P. I.; Persaud, Y.; Janakiraman, M.; Kong, X.; Ng, C.; Moriceau, G.; Shi, H.; Atefi, M.; Titz, B.; Gabay, M. T.; more...
    Cancer Research (2012)

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  • Resistance to RAF inhibitors due to RAS-independent dimerization of BRAF(V600E) splicing variants
    Meeting Abstract

    Poulikakos, P. I.; Persaud, Y.; Janakiraman, M.; Gabay, M. T.; Dahlman, K. B.; Sosman, J. A.; Ribas, A.; Lo, R. S.; Rosen, N.; Solit, D. B.
    European Journal of Cancer (2012)

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  • Genomic complexity and AKT dependence in serous ovarian cancer
    Journal Article

    Hanrahan, A. J.; Schultz, N.; Westfal, M. L.; Sakr, R. A.; Giri, D. D.; Scarperi, S.; Janakiraman, M.; Olvera, N.; Stevens, E. V.; She, Q. B.; more...
    Cancer Discovery (2012)

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  • An in-frame deletion in the N-terminal regulatory domain of BRAF(V600E) causes resistance to the RAF inhibitor PLX4032
    Meeting Abstract

    Poulikakos, P. I.; Persaud, Y.; Gabay, M. T.; Janakiraman, M.; Joseph, E. W.; Pratilas, C. A.; Chapman, P. B.; Rosen, N.; Solit, D. B.
    Cancer Research (2011)

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  • RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)
    Journal Article

    Poulikakos, P. I.; Persaud, Y.; Janakiraman, M.; Kong, X.; Ng, C.; Moriceau, G.; Shi, H.; Atefi, M.; Titz, B.; Gabay, M. T.; more...
    Nature (2011)

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  • Concurrent loss of PTEN and RB is sufficient to confer BRAF independence in melanomas harboring V600E BRAF mutations
    Meeting Abstract

    Xing, F.; Persaud, Y.; Pratilas, C.; Janakiraman, M.; She, Q. B.; Liu, C.; Dolgalev, I.; Heguy, A.; Wolchok, J.; Cobrinik, D.; more...
    Cancer Research (2010)

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  • Genetic determinants of AKT-dependence in epithelial ovarian cancer
    Meeting Abstract

    Hanrahan, A. J.; Scarperi, S.; Sakr, R. A.; Westfal, M. L.; Godsell, J.; Janakiraman, M.; Levine, D. A.; She, Q. B.; Rosen, N.; Solit, D. B.
    Cancer Research (2010)

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  • Genetic predictors of MEK dependence in V600E BRAF mutant melanoma
    Meeting Abstract

    Xing, F.; Pratilas, C.; Persaud, Y.; Janakiraman, M.; Houghton, A.; Rosen, N.; Solit, D.
    Cancer Research (2009)

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  • Identification and biological characterization of exon 4 KRAS mutations by MALDI-TOF Mass Spectrometry based genotyping
    Meeting Abstract

    Janakiraman, M.; Zeng, Z.; Chitale, D.; Halilovic, E.; Rosen, N.; Vakiani, E.; Heguy, A.; Ladanyi, M.; Jhanwar, S.; Saltz, L.; more...
    Cancer Research (2009)

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  • Amplification of wild-type BRAF in melanoma is associated with activation of RAF-MEK-ERK signaling and MEK-dependence
    Meeting Abstract

    Blumenthal, E.; Poulikakos, P. I.; Tadi, M.; Grbovic-Huezo, O.; Taylor, B. S.; Janakiraman, M.; Leversha, M.; Viale, A.; Solit, D. B.; Rosen, N.; more...
    Cancer Research (2009)

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