Synapse - Romel Somwar

Results (110)

Identification and preliminary characterization of novel small molecules that inhibit growth of human lung adenocarcinoma cells

Journal Article

Somwar, R.; Shum, D.; Djaballah, H.; Varmus, H.
Journal of Biomolecular Screening (2009)

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An integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR-mutant tumors

Journal Article

Chitale, D.; Gong, Y.; Taylor, B. S.; Broderick, S.; Brennan, C.; Somwar, R.; Golas, B.; Wang, L.; Motoi, N.; Szoke, J.; more...
Oncogene (2009)

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An integrated analysis of gene expression, copy number alterations, and kinase pathway mutations in lung adenocarcinoma reveals frequent loss of the MAPK phosphatase Gene DUSP4 in EGFR mutant tumors

Meeting Abstract

Chitale, D.; Gong, Y.; Broderick, S.; Brennan, C.; Taylor, B. S.; Somwar, R.; Wang, L.; Motoi, N.; Szoke, J.; Sander, C.; more...
Laboratory Investigation (2008)

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An integrated analysis of gene expression, copy number alterations, and kinase pathway mutations in lung adenocarcinoma reveals frequent loss of the MAPK phosphatase gene DUSP4 in EGFR mutant tumors

Meeting Abstract

Chitale, D.; Gong, Y.; Broderick, S.; Brennan, C.; Taylor, B. S.; Somwar, R.; Wang, L.; Motoi, N.; Szoke, J.; Sander, C.; more...
Modern Pathology (2008)

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Identifying strategies to enhance responses induced by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas

Meeting Abstract

Gong, Y.; Somwar, R.; Politi, K.; Balak, M.; Chmielecki, J.; Jiang, X.; Pao, W.
Molecular Cancer Therapeutics (2007)

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Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas

Journal Article

Gong, Y.; Somwar, R.; Politi, K.; Balak, M.; Chmielecki, J.; Jiang, X.; Pao, W.
PLos Medicine (2007)

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Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors

Journal Article

Balak, M. N.; Gong, Y.; Riely, G. J.; Somwar, R.; Li, A. R.; Zakowski, M. F.; Chiang, A.; Yang, G.; Ouerfelli, O.; Kris, M. G.; more...
Clinical Cancer Research (2006)

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Models of type 2 diabetes

Journal Article

Somwar, R.; Fang, X.; Sweeney, G.
Drug Discovery Today: Disease Models (2005)

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Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain

Journal Article

Pao, W.; Miller, V. A.; Politi, K. A.; Riely, G. J.; Somwar, R.; Zakowski, M. F.; Kris, M. G.; Varmus, H.
PLos Medicine (2005)

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Globular adiponectin increases GLUT4 translocation and glucose uptake but reduces glycogen synthesis in rat skeletal muscle cells

Journal Article

Ceddia, R. B.; Somwar, R.; Maida, A.; Fang, X.; Bikopoulos, G.; Sweeney, G.
Diabetologia (2005)

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