Research Focus

Former Employee. Structural Biology; Senior Research Scientist

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1. Methylation of cytosine at C5 in a CpG sequence context causes a conformational switch of a benzo[a]pyrene diol epoxide-N2-guanine adduct in DNA from a minor groove alignment to intercalation with base displacement

   Journal Article

   Zhang, N.; Lin, C.; Huang, X.; Kolbanovskiy, A.; Hingerty, B. E.; Amin, S.; Broyde, S.; Geacintov, N. E.; Patel, D. J.
   Journal of Molecular Biology (2005)

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2. Methylation of cytosine in a C-(BP)G sequence context selectively switches the conformation of (-)-trans-anti-(BP)G adduct, but not its (+)-trans-anti-counterpart, from a minor groove alignment of the BP adduct, to intercalation with a base displacement alignment

   Meeting Abstract

   Lin, C.; Zhang, N.; Huang, X.; Kolbanoviskiy, A.; Hingerty, B. E.; Broyde, S.; Geacintov, N. E.; Patel, D. J.
   Proceedings of the American Association for Cancer Research Annual Meeting (2003)

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3. Molecular topology of polycyclic aromatic carcinogens determines DNA adduct conformation: A link to tumorigenic activity

   Journal Article

   Lin, C. H.; Huang, X.; Kolbanovskii, A.; Hingerty, B. E.; Amin, S.; Broyde, S.; Geacintov, N. E.; Patel, D. J.
   Journal of Molecular Biology (2001)

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