Research Focus

Chemical Biology Program; Member

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1. The pan-RAF–MEK nondegrading molecular glue NST-628 is a potent and brain-penetrant inhibitor of the RAS–MAPK pathway with activity across diverse RAS-and RAF-driven cancers

   Journal Article

   Ryan, M. B.; Quade, B.; Schenk, N.; Fang, Z.; Zingg, M.; Cohen, S. E.; Swalm, B. M.; Li, C.; Özen, A.; Ye, C.; more...
   Cancer Discovery (2024)

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2. Live-cell target engagement of allosteric MEKi on MEK–RAF/KSR–14-3-3 complexes

   Journal Article

   Marsiglia, W. M.; Chow, A.; Khan, Z. M.; He, L.; Dar, A. C.
   Nature Chemical Biology (2024)

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3. WNTinib is a multi-kinase inhibitor with specificity against β-catenin mutant hepatocellular carcinoma

   Journal Article

   Rialdi, A.; Duffy, M.; Scopton, A. P.; Fonseca, F.; Zhao, J. N.; Schwarz, M.; Molina-Sanchez, P.; Mzoughi, S.; Arceci, E.; Abril-Fornaguera, J.; more...
   Nature Cancer (2023)

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