Research Focus

Former Employee. Developmental Therapy

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1. Facilitated transport of methotrexate polyglutamates into lysosomes derived from S180 cells: Further characterization and evidence for a simple mobile carrier system with broad specificity for homo- or heteropeptides bearing a C-terminal glutamyl moiety

   Journal Article

   Barrueco, J. R.; O'Leary, D. F.; Sirotnak, F. M.
   Journal of Biological Chemistry (1992)

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2. Metabolic turnover of methotrexate polyglutamates in lysosomes derived from S180 cells: Definition of a two-step process limited by mediated lysosomal permeation of polyglutamates and activating reduced sulfhydryl compounds

   Journal Article

   Barrueco, J. R.; O'Leary, D. F.; Sirotnak, F. M.
   Journal of Biological Chemistry (1992)

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3. Evidence for the facilitated transport of methotrexate polyglutamates into lysosomes derived from S180 cells: Basic properties and specificity for polyglutamate chain length

   Journal Article

   Barrueco, J. R.; Sirotnak, F. M.
   Journal of Biological Chemistry (1991)

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