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David Solit

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Inhibition of heat shock protein 90 function down-regulates Akt kinase and sensitizes tumors to Taxol

Journal Article

Solit, D. B.; Basso, A. D.; Olshen, A. B.; Scher, H. I.; Rosen, N.
Cancer Research (2003)

Pilot study of epothilone B analog (BMS-247550) and estramustine phosphate in patients with progressive metastatic prostate cancer following castration

Journal Article

Smaletz, O.; Galsky, M.; Scher, H. I.; Delacruz, A.; Slovin, S. F.; Morris, M. J.; Solit, D. B.; Davar, U.; Schwartz, L.; Kelly, W. K.
Annals of Oncology (2003)

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Resistance to gefitinib in PTEN-Null HER-overexpressing tumor cells can be overcome through restoration of PTEN function or pharmacologic modulation of constitutive phosphatidylinositol 3′-kinase/Akt pathway signaling

Journal Article

She, Q. B.; Solit, D.; Basso, A.; Moasser, M. M.
Clinical Cancer Research (2003)

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Combination treatment with 17-N-allylamino-17-demethoxy geldanamycin and acute irradiation produces supra-additive growth suppression in human prostate carcinoma spheroids

Journal Article

Enmon, R.; Yang, W. H.; Ballangrud, A. M.; Solit, D. B.; Heller, G.; Rosen, N.; Scher, H. I.; Sgouros, G.
Cancer Research (2003)

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Angiogenesis impairment in Id-deficient mice cooperates with an Hsp90 inhibitor to completely suppress HER2/neu-dependent breast tumors

Journal Article

De Candia, P.; Solit, D. B.; Giri, D.; Brogi, E.; Siegel, P. M.; Olshen, A. B.; Muller, W. J.; Rosen, N.; Benezra, R.
Proceedings of the National Academy of Sciences of the United States of America (2003)

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Chemotherapy for androgen-independent prostate cancer

Book Section

Solit, D. B.; Kelly, W. K.
In Kantoff, P. W.; Carroll, P. R.; D'Amico, A. V. (Eds.) Prostate Cancer: Principles & Practice. 1st ed (2002)

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G1 arrest of prostate cancer cells by antiandrogens is associated with reduction of Skp2 expression and rapid p27-independent loss in cyclin E-associated kinase activity

Meeting Abstract

Zheng, F.; Lobo, J.; Solit, D.; Rosen, N.; Scher, H.
Proceedings of the American Association for Cancer Research Annual Meeting (2002)

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Identification and synthesis of novel small molecules that bind to and modulate Hsp90 function

Meeting Abstract

Solit, D. B.; Basso, A.; Huezo, H.; Shtil, A.; Rosen, N.; Chiosis, G.
Proceedings of the American Association for Cancer Research Annual Meeting (2002)

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Ras signaling is not required for transformed growth but does mediate the angiogenic properties of MCF-7 cells

Meeting Abstract

Moasser, M. M.; Solit, D.; Costa, C.; Rafii, S.; Rosen, N.
Proceedings of the American Association for Cancer Research Annual Meeting (2002)

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Synergistic interaction of a geldanamycin analog (17AAG) and radiation in human prostate tumor spheroids

Meeting Abstract

Enmon, R. M.; Yang, W.; Solit, D. B.; Ballangrud, A. M.; Rosen, N.; Scher, H. I.; Sgouros, G.
Proceedings of the American Association for Cancer Research Annual Meeting (2002)

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