Synapse - David Solit

Results (783)

Response and resistance to gefitinib (ZD1839, Iressa) in HER overexpressing tumor cells is mediated through the PI3K/Akt pathway

Meeting Abstract

She, Q. B.; Solit, D.; Basso, A.; Rosen, N.; Moasser, M. M.
Proceedings of the American Association for Cancer Research Annual Meeting (2003)

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Phase I trial to evaluate J591 as a vascular targeting agent in patients with advanced solid tumors

Meeting Abstract

Morris, M. J.; Divgi, C.; Kelly, W. K.; Slovin, S.; Solit, D.; Shaffer, D.; Halpern, J.; Delacruz, A.; Curley, T.; Nacca, A.; more...
Proceedings of the American Association for Cancer Research Annual Meeting (2003)

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Pulsatile administration of the EGF receptor inhibitor gefitinib (Iressa, ZD 1839) is significantly more effective than continuous dosing for sensitizing tumors to Taxol

Meeting Abstract

Solit, D. B.; She, Y.; Moasser, M.; Hudis, C.; Kris, M.; Scher, H.; Rosen, N.; Sirotnak, F. M.
Clinical Cancer Research (2003)

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Rapid MicroPET imaging of 17AAG induced HER2 protein downregulation using Ga-68-DOTA-F(ab ')(2) herceptin

Meeting Abstract

Smith-Jones, P. M.; Solit, D.; Afroze, F.; Akhurst, T.; Rosen, N.; Larson, S. M.
Journal of Nuclear Medicine (2003)

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Cyclin D expression and G1 progression are dependent on MEK-MAP kinase activity in tumor cells with B-Raf mutation but not in breast cancer cells with wild type Ras

Meeting Abstract

Sawai, A.; Basso, A. D.; Solit, D. B.; She, Q. B.; Grbovic, O.; Pratilas, C.; Chapman, P.; Moasser, M. M.; Rosen, N.
Clinical Cancer Research (2003)

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Activated, mutated B-Raf protein kinase requires the Hsp90 chaperone protein for folding and stability and is degraded in response to Hsp90 inhibitors

Meeting Abstract

Grbovic, O. M.; Basso, A. D.; Houghton, A.; Solit, D. B.; Rosen, N.
Clinical Cancer Research (2003)

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Hsp90 as a therapeutic target in prostate cancer

Journal Article

Solit, D. B.; Scher, H. I.; Rosen, N.
Seminars in Oncology (2003)

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Development of purine-scaffold small molecule inhibitors of Hsp90

Journal Article

Chiosis, G.; Lucas, B.; Huezo, H.; Solit, D.; Basso, A.; Rosen, N.
Current Cancer Drug Targets (2003)

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Total synthesis as a resource in the discovery of potentially valuable antitumor agents: Cycloproparadicicol

Journal Article

Yamamoto, K.; Garbaccio, R. M.; Stachel, S. J.; Solit, D. B.; Chiosis, G.; Rosen, N.; Danishefsky, S. J.
Angewandte Chemie - International Edition (2003)

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Clinical experience with intravenous estramustine phosphate, paclitaxel, and carboplatin in patients with castrate, metastatic prostate adenocarcinoma

Journal Article

Solit, D. B.; Morris, M.; Slovin, S.; Curley, T.; Schwartz, L.; Larson, S.; Kattan, M. W.; Hartley-Asp, B.; Scher, H. I.; Kelly, W. K.
Cancer (2003)

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