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Taha Merghoub

  1. "David Schaer"
Formats
  1. Meeting Abstract (9)
  2. Journal Article (6)
Groups
  1. Department of Medicine (15)
  2. Melanoma and Immunotherapeutics Service (15)
  3. Solid Tumor Oncology Division (15)
  4. GSK Faculty (13)
  5. Sloan Kettering Institute Postdocs (12)
  6. Immunology Program Faculty (6)

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People
  1. David Schaer (15)
  2. Jedd Wolchok (13)
  3. Sadna Budhu (9)
  4. Cailian Liu (7)
  5. Hong Zhong (7)
  6. Xia Yang (7)

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Years
  1. 2020 (1)
  2. 2019 (2)
  3. 2018 (2)
  4. 2017 (3)
  5. 2016 (2)
  6. 2013 (3)

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Publications
  1. Journal for ImmunoTherapy of Cancer (4)
  2. PLoS ONE (3)
  3. Cancer Immunology Research (2)
  4. Cancer Research (2)
  5. Journal of Clinical Oncology (1)
  6. Journal of Immunology (1)

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Publishers
  1. American Association for Cancer Research (4)
  2. Biomed Central Ltd (4)
  3. Public Library of Science (3)
  4. American Association for the Advancement of Science (1)
  5. American Society of Clinical Oncology (1)
  6. Nature Publishing Group (1)

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Results (15)

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  • Overcoming immune resistance with rationally designed combination immunotherapy
    Meeting Abstract

    Zappasodi, R.; Budhu, S.; Sirard, C.; Qi, J.; Liu, C.; Li, Y.; Senbabaoglu, Y.; Manne, S.; Gasmi, B.; Zhong, H.; more...
    Cancer Research (2020)

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  • Rational combination of GITR agonism with PD-1 blockade
    Meeting Abstract

    Zappasodi, R.; Sirard, C.; Li, Y.; Budhu, S.; Abu-Akeel, M.; Liu, C.; Yang, X.; Zhong, H.; Newman, W.; Qi, J.; more...
    Cancer Research (2019)

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  • Rational design of anti-GITR-based combination immunotherapy
    Journal Article

    Zappasodi, R.; Sirard, C.; Li, Y.; Budhu, S.; Abu-Akeel, M.; Liu, C.; Yang, X.; Zhong, H.; Newman, W.; Qi, J.; more...
    Nature Medicine (2019)

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  • Rational combination of GITR agonism with PD-1 blockade in cancer patients
    Meeting Abstract

    Zappasodi, R.; Sirard, C.; Li, Y.; Budhu, S.; Abu-Akeel, M.; Liu, C.; Yang, X.; Zhong, H.; Newman, W.; Qi, J.; more...
    Journal for ImmunoTherapy of Cancer (2018)

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  • Toxicological and pharmacological assessment of AGEN1884, a novel human IgG1 anti-CTLA-4 antibody
    Journal Article

    Gombos, R. B.; Gonzalez, A.; Manrique, M.; Chand, D.; Savitsky, D.; Morin, B.; Breous-Nystrom, E.; Dupont, C.; Ward, R. A.; Mundt, C.; more...
    PLoS ONE (2018)

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  • Characterization of the anti-CTLA-4 antibody AGEN1884, including toxicology and pharmacology assessments in non-human primates
    Meeting Abstract

    Gombos, R.; Gonzalez, A.; Manrique, M.; Chand, D.; Savitsky, D.; Morin, B.; Breous-Nystrom, E.; Dupont, C.; Ward, R.; Mundt, C.; more...
    Journal for ImmunoTherapy of Cancer (2017)

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  • AGEN2034, a novel anti-PD-1 antibody that combines effectively with CTLA-4 pathway blockade to enhance T cell activity
    Meeting Abstract

    Chand, D.; Savitsky, D.; Gonzalez, A.; Clarke, C.; Schuster, A.; Drouin, E. E.; Waight, J. D.; Mundt, C.; Ritter, G.; Merghoub, T.; more...
    Journal for ImmunoTherapy of Cancer (2017)

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  • Blockade of surface-bound TGF-ß on regulatory T cells abrogates suppression of effector T cell function in the tumor microenvironment
    Journal Article

    Budhu, S.; Schaer, D. A.; Li, Y.; Toledo-Crow, R.; Panageas, K.; Yang, X.; Zhong, H.; Houghton, A. N.; Silverstein, S. C.; Merghoub, T.; more...
    Science Signaling (2017)

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  • First-in-human phase 1 single-dose study of TRX-518, an anti-human glucocorticoid-induced tumor necrosis factor receptor (GITR) monoclonal antibody in adults with advanced solid tumors
    Meeting Abstract

    Koon, H. B.; Shepard, D. R.; Merghoub, T.; Schaer, D. A.; Sirard, C. A.; Wolchok, J. D.
    Journal of Clinical Oncology (2016)

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  • Treg inhibition by anti-GITR therapy evokes therapeutic antitumor responses selectively in the context of a pro-inflammatory tumor microenvironment
    Meeting Abstract

    Zappasodi, R.; Budhu, S.; Liu, C.; Draleau, K.; Schaer, D.; Zhong, H.; Yang, X.; Merghoub, T.; Wolchok, J. D.
    Cancer Immunology Research (2016)

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