Synapse - Neal Rosen

Results (425)

Identification of a geldanamycin dimer that induces the selective degradation of HER-family tyrosine kinases

Journal Article

Zheng, F. F.; Kuduk, S. D.; Chiosis, G.; Münster, P. N.; Sepp-Lorenzino, L.; Danishefsky, S. J.; Rosen, N.
Cancer Research (2000)

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A peptidomimetic inhibitor of ras functionality markedly suppresses growth of human prostate tumor xenografts in mice. Prospects for long-term clinical utility

Journal Article

Sirotnak, F. M.; Sepp-Lorenzino, L.; Kohl, N. E.; Rosen, N.; Scher, H. I.
Cancer Chemotherapy and Pharmacology (2000)

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Synthesis and evaluation of geldanamycin-testosterone hybrids

Journal Article

Kuduk, S. D.; Harris, C. R.; Zheng, F. F.; Sepp-Lorenzino, L.; Ouerfelli, O.; Rosen, N.; Danishefsky, S. J.
Bioorganic & Medicinal Chemistry Letters (2000)

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Pharmacokinetics and pharmacodynamics of the farnesyl protein transferase inhibitor (L-778,123) in solid tumors

Meeting Abstract

Soignet, S.; Yao, S. L.; Britten, C.; Spriggs, D.; Pezzulli, S.; McCreery, H.; Mazina, K.; Deutsch, P.; Lee, Y.; Lobell, R.; more...
Proceedings of the American Association for Cancer Research Annual Meeting (1999)

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Inhibitor of src kinases produces mitotic block in cancer cells

Meeting Abstract

Moasser, M. M.; Strethapakdi, M.; Sachar, S.; Rosen, N.
Proceedings of the American Association for Cancer Research Annual Meeting (1999)

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Farnesyltransferase inhibitor (FTI) and EGF receptor (EGFR) blockade induced a synergistic G(1) arrest in H-Ras-transformed human breast epithelial cells

Meeting Abstract

Chou, J. L.; Moasser, M.; Sepp-Lorenzino, L.; Mendelsohn, J.; Norton, L.; Rosen, N.
Proceedings of the American Association for Cancer Research Annual Meeting (1999)

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Herbimycin A reveals a role for Rb in mitosis

Meeting Abstract

Srethapakdi, M.; Moasser, M.; Rosen, N.
Proceedings of the American Association for Cancer Research Annual Meeting (1999)

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Inductin of differentiation and apoptosis in human breast cancer cell lines by the modified geldanamycin (17-AAG)

Meeting Abstract

Münster, P. N.; Zheng, F. F.; Sepp-Lorenzino, L.; Sausville, E. A.; Rosen, N.
Proceedings of the American Association for Cancer Research Annual Meeting (1999)

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The Hsp90 chaperone system as a potential therapeutic target: Identification of a geldanamycin dimer that induces the selective degradation of HER-family tyrosine kinases

Meeting Abstract

Zheng, F. Z. F.; Münster, P. N.; Kuduk, S.; Danishefsky, S.; Sepp-Lorenzino, L.; Rosen, N.
Clinical Cancer Research (1999)

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Induction of differentiation and apoptosis in human breast cancer cell lines by modified geldanamycin derivatives (17-AAG)

Meeting Abstract

Münster, P. N.; Zheng, F. F.; Srethapakdi, M.; Sausville, E.; Rosen, N.
Clinical Cancer Research (1999)

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