Synapse - Neal Rosen

Results (426)

Cyclin D expression and G1 progression are dependent on MEK MAP kinase activity in tumor cells with B-Raf mutation but not in breast cancer cells with wild type Ras and Raf

Meeting Abstract

Sawai, A.; Pratilas, C.; Basso, A.; Rosen, N.; Solit, D. B.
Cancer Research (2005)

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The MEK inhibitor PD0325901 completely inhibits the growth of melanoma tumors with mutationally activated B-Raf

Meeting Abstract

Pratilas, C.; Sawai, A.; Ye, Q.; Lobo, J.; She, Y.; Sebolt-Leopold, J.; Rosen, N.; Solit, D.
Cancer Research (2005)

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The IGF-1 dependent feedback activation of AKT

Meeting Abstract

Oreilly, K. E.; She, Q. B.; Solit, D.; Lane, H.; Hofmann, F.; Hicklin, D. J.; Baselga, J.; Rosen, N.
Cancer Research (2005)

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V599E B-Raf as the next HSP90 client protein: A novel strategy for selective inhibition of mutated B-Raf

Meeting Abstract

Grbovic, O. M.; Basso, A.; Solit, D.; Rosen, N.
Cancer Research (2005)

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Treatment of melanoma patients with 17AAG results in downregulation of the MAPK pathway in the melanoma tumors

Meeting Abstract

Friedlander, P.; Solit, D.; Osman, I.; Polsky, D.; Elamparo, R.; Rosen, N.; Chapman, P. B.
Cancer Research (2005)

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Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90

Meeting Abstract

Chiosis, G.; He, H.; Llauger, L.; Rosen, N.; Kim, J.; Aguirre, J.
Cancer Research (2005)

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FLT PET as a non-invasive marker of response to MEK inhibition

Meeting Abstract

Solit, D. B.; Santos, E.; Pratilas, C.; Moroz, M.; Blasberg, R.; Sebolt-Leopold, J.; Larson, S. M.; Rosen, N.
Clinical Cancer Research (2005)

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Phase 1 pharmacokinetic and pharmacodynamic trial of docetaxel and 17AAG (17-allylamino-17-demethoxygeldanamycin)

Meeting Abstract

Solit, D. B.; Egorin, M.; Kopil, C.; Delacruz, A.; Shaffer, D.; Slovin, S.; Morris, M.; Kelly, W. K.; Rosen, N.; Scher, H.
Journal of Clinical Oncology (2005)

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Inhibitors of Hsp90 induce the degradation of HER2 and inhibit the growth of HER2-dependent breast tumors

Meeting Abstract

Solit, D. B.; Basso, A.; Smith-Jones, P.; Modi, S.; Norton, L.; Larson, S.; Neckers, L.; Scher, H.; Hudis, C.; Rosen, N.
Breast Cancer Research and Treatment (2005)

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Genetic and pharmacological inhibition of p13 kinase signaling in vivo sensitizes tumors to EGFR inhibitors and to taxol

Meeting Abstract

She, Q. B.; Ye, Q.; She, Y. H.; Solit, D.; Gibbons, J.; Rosen, N.
Clinical Cancer Research (2005)

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